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三、异单基因近交系
...代才能建立同类系，因此要在括号内标明回交代数，如C57BL/6-Wv+(N8)。（Wv是“活显性白斑”基因，是W的等位基因）。至于代数计数，是把第一次杂交（bybrid）的F1计算为第一代，第一次回交所产生的下代计算为第二代，以此类推...
医源资料库；医源图书馆；教材类；医用实验动物学 -
Transplantationofspermatogonialstemcellsisolatedfromleukemicmicerestoresfertilitywithoutinducingleukemia
...tssurvivechildhoodleukemia,butchemotherapyandradiationtherapycauseirreversibleimpairmentofspermatogenesis.Althoughautotransplantationofgermcellsholdspromiseforrestoringfertility,contaminationbyleukemiccellsmayinducerelapse.Inthisstudy,weisolatedgermcellsfromleukemicmicebyFACSsorting.Thecellpopulatio...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第7期 -
LowplasmareninandreducedreninsecretoryresponsestoacutestimuliinconsciousCOX-2-deficientmice
...andcyclooxygenase(COX)-2-/-miceonthreedifferentgeneticbackgrounds(mixed,C57BL/6,129J).PRCwasmeasuredinplasmaobtainedbytailveinpuncture.BasalPRCwassignificantlylowerinCOX-2-/-thanWTmiceindependentofgeneticbackground(51,10,and17%ofWTinmixed,129J,andC57BL/6).Allfiveacuteinterventionscausedsignificantin...
医源资料库；在线期刊；美国生理学杂志；2007年第290卷第1期 -
RateofGranulocyteMacrophageColony-StimulatingFactorinHostDefenseAgainstPulmonaryCryptococcusneoformansInfectionduringMurineAllergicBronchopul
...healinoculationofCryptococcusneoformans.PulmonaryC.neoformansinfectionofC57BL/6miceisanestablishedmodelofanallergicbronchopulmonarymycosis.OurobjectivewastodeterminewhetherGM-CSFregulatesthepulmonaryTh2immuneresponseinC.neoformans-infectedC57BL/6mice.Long-termpulmonaryfungistasiswaslostinGM-CSFknock...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第3期 -
MouseStrain–SpecificDifferencesinVascularWallGeneExpressionandTheirRelationshiptoVascularDisease
...itdifferentsusceptibilitytothedevelopmentofatherosclerosis.TheC3H/HeJandC57Bl/6micehavebeenusedinseveralstudiesaimedatunderstandingthegeneticbasisofatherosclerosis.Undercontrolledenvironmentalconditions,variationsinsusceptibilitytoatherosclerosisreflectdifferencesingeneticmakeup,andthesedifferencesm...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第2期 -
ImmunolocalizationofproteinkinaseCisoenzymes,I,II,,andinmousekidney
...lizationofproteinkinaseC(PKC)isoenzymes,I,II,,andwasstudiedemployingWesternblotanalysisandimmunohistochemicalmethodsincludingconfocallaser-scanningmicroscopyinthekidneyoftwomicestrains,namely,C57BL/6and129/Sv,whichhaverecentlybeenusedasgeneticbackgroundsforrespectiveknockoutmice.Immunoblotanalysisid...
医源资料库；在线期刊；美国生理学杂志；2004年第287卷第8期 -
NKcellspromotetransplanttolerancebykillingdonorantigen-presentingcells
...eTcells.TcellsactivatedintheabsenceofNKcellsaremoreresistanttocostimulatoryblockadetreatment,andundersuchconditionsstableskinallograftsurvivalisdifficulttoachieve.OurstudyidentifiedanovelroleforNKcellsinregulatingTcellprimingintransplantmodels,andmayhaveimportantclinicalimplicationsintoleranceinduct...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第8期 -
全身照射方案和骨髓细胞移植量对小鼠异基因骨髓移植成功率的影响
...胞移植量对小鼠异基因骨髓移植存活率的影响。方法以C57BL/6J（H-2b）及其GFP转基因小鼠为供体、BALB/c（H-2d）小鼠为受体，进行异基因骨髓移植。为观察移植时间对存活率的影响，把24只小鼠平分为2组，分别在TBI9.0Gy后4h、24h移植1...
合作平台；在线期刊；中华医学研究杂志；2004年第4卷第7期；论著 -
中药猫眼草对小鼠Lewis肺癌细胞凋亡的影响
［摘要］目的探讨中药猫眼草对C57BL/6小鼠Lewis肺癌细胞凋亡的影响。方法将Lewis肺癌C57BL/6小鼠分为模型组、猫眼草7.5、15.0、30.0、60.0g/kg组和顺铂组，应用流式细胞仪和TUNEL法检测猫眼草对Lewis肺癌细胞凋亡的影响。结果猫眼草30.0...
医源资料库；在线期刊；齐鲁医学杂志；2006年第21卷第6期 -
Suppressionofallergicairwayinflammationbyhelminth-inducedregulatoryTcells
...ethatTh2cell–stimulatinghelminthparasitesmayalsocounteractallergies,possiblybygeneratingregulatoryTcellswhichsuppressbothTh1andTh2armsofimmunity.WethereforetestedtheabilityoftheTh2cell–inducinggastrointestinalnematodeHeligmosomoidespolygyrustoinfluenceexperimentallyinducedairwayallergytoovalbumi...
医源资料库；在线期刊；实验医学杂志；2005年第202卷第9期