SusceptibilityofHumanTestistoHumanImmunodeficiencyVirus-InfectioninSituandinVitro
...rustosemen.HereweinvestigatedthepresenceofHIVreceptorswithinthehumantestisusingimmunohistochemistryandquantitativereal-timepolymerasechainreaction.WealsoanalyzedtheinfectivityofadualtropicHIV-1straininanorganotypicculture,aswellastheimpactofviralexposureontestosteroneproduction.Ourstudyestablishesth...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期Epidermalbarrierformationandrecoveryinskindisorders
...alth,Bethesda,Maryland,USA.AbstractSkinisattheinterfacebetweenthecomplexphysiologyofthebodyandtheexternal,oftenhostile,environment,andthesemipermeableepidermalbarrierpreventsboththeescapeofmoistureandtheentryofinfectiousortoxicsubstances.Newbornswithrarecongenitalbarrierdefectsunderscoretheskin’se...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期TheThiazolidinedionePioglitazoneAltersMitochondrialFunctioninHumanNeuron-LikeCells
...Thiazolidinedionesaltercellenergymetabolism.Theyareusedtotreatorarebeingconsideredforthetreatmentofdisordersthatfeaturemitochondrialimpairment.Theirmitochondrialeffects,however,havenotbeencomprehensivelystudiedunderlong-termexposureconditions.Weusedthehumanneuron-likeNT2celllinetodirectlyassessthelo...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期Avirus-encodedtelomeraseRNApromotesmalignantTcelllymphomagenesis
DepartmentofMicrobiologyandImmunology,CornellUniversity,Ithaca,NY14853DepartmentofAnimalandFoodScience,UniversityofDelaware,Newark,DE19717InstituteforAnimalHealth,Compton,BerkshireRG207NN,UKTelomeraseisaribonucleoproteincomplexconsistingoftwoessentialcorecomponents:areversetranscriptaseandanRNAsubun...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第5期ActivationofTRPA1ChannelsbytheFattyAcidAmideHydrolaseInhibitor3‘-Carbamoylbiphenyl-3-ylcyclohexylcarbamate(URB597)
【关键词】ActivationAsamemberofthetransientreceptorpotential(TRP)ionchannelsuperfamily,theligand-gatedionchannelTRPA1hasbeenimplicatedinnociceptivefunctionandpainstates.TheendogenousligandsthatactivateTRPA1remainunknown.However,variousagonistshavebeenidentified,includingenvironmentalirritants(e...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第5期cGMPCatabolismbyPhosphodiesterase5ARegulatesCardiacAdrenergicStimulationbyNOS3-DependentMechanism
FromtheDivisionofCardiology(E.T.,H.C.C.,D.B.,J.M.,T.I.,D.A.K.),DepartmentofMedicine,JohnsHopkinsMedicalInstitutions,Baltimore,Md;DulbeccoTelethonInstituteattheVenetianInstituteofMolecularMedicine(M.M.,M.Z.),Padova,Italy;DepartmentofPharmacologyandToxicology(E.M.),Ruhr-UniversittBochum,MedizinischeFa...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第1期ThromboxaneA2PromotesInterleukin-6BiosynthesisMediatedbyanActivationofCyclicAMP-ResponseElement-BindingProteinin1321N1HumanAstrocytomaCells
DepartmentofCellularSignaling,21stCOEprogram“CRESCENDO“,GraduateSchoolofPharmaceuticalSciences,TohokuUniversity,Sendai,Japan(Y.O.,N.N.)DepartmentofPharmacologyandToxicology,GraduateSchoolofPharmaceuticalSciences,KyushuUniversity,Fukuoka,Japan(H.K.)Abstract1321N1humanastrocytomacellsexpressthromb...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期RenalfunctionmeasurementsfromMRrenographyandasimplifiedmulticompartmentalmodel
...Thepurposeofthisstudywastodeterminetheaccuracyandsourcesoferrorinestimatingsingle-kidneyglomerularfiltrationrate(GFR)derivedfromlow-dosegadolinium-enhancedT1-weightedMRrenography.Toanalyzeimagingdata,MRsignalintensitycurveswereconvertedtoconcentrationvs.timecurves,andathree-compartment,six-parameter...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期Gq-MediatedActivationofc-JunN-TerminalKinasebytheGastrin-ReleasingPeptide-PreferringBombesinReceptorIsInhibiteduponCostimulationoftheGs-Coup
...echnologyResearchInstitute,andtheMolecularNeuroscienceCenter,HongKongUniversityofScienceandTechnology,ClearWaterBay,Kowloon,HongKongAbstractGprotein-coupledreceptors(GPCRs)ofGi-orGq-couplingspecificityareeffectivelylinkedtoactivationofthec-JunN-terminalkinase(JNK)cascade.However,littleisknownwithreg...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期Evidenceforpotentialmechanismsfortheeffectofconjugatedlinoleicacidontumormetabolismandimmunefunction:lessonsfromn3fattyacids
...ciaDSchley1FromtheDepartmentofAgricultural,FoodandNutritionalScience,UniversityofAlberta,Edmonton,Canada2Presentedattheworkshop“TheRoleofConjugatedLinoleicAcidinHumanHealth,“heldinWinnepeg,Canada,March1315,2003.3SupportedbytheNaturalSciencesandEngineeringResearchCouncilofCanadaand3memberso...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第6期