EriocalyxinBInhibitsNuclearFactor-BActivationbyInterferingwiththeBindingofBothp65andp50totheResponseElementinaNoncompetitiveManner
...ment-bindingprotein.ItsuppressedthetranscriptionofNF-Bdownstreamgeneproductsincludingcyclooxygenase-2andinduciblenitric-oxidesynthaseinducedbytumornecrosisfactor-orlipopolysaccharideinmacrophagesandhepatocarcinomacells.ChromatinimmunoprecipitationassayindicatedthatEri-Bselectivelyblockedthebindingbe...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期RapidPed-2E9Cell-BasedCytotoxicityAnalysisandGenotypingofBacillusSpecies
MolecularFoodMicrobiologyLaboratory,DepartmentofFoodScience,PurdueUniversity,WestLafayette,Indiana47907ABSTRACTBacillusspeciescausingfood-bornediseaseproducemultipletoxinselicitinggastroenteritis.Toxinassayswithmammaliancellculturesarereliablebutmaytake24to72htocompleteandalsolacksensitivity.Here,as...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期TheRoleofPlateletsinLeukocyteRecruitmentinChronicContactHypersensitivityInducedbyRepeatedElicitation
...oleinchronicallergicdermatitisremainsunclear.Toinvestigatetheroleofplateletsinamousemodelofchroniccontacthypersensitivityinducedbyrepeatedelicitation,miceweresensitizedandrepeatedlyelicitedinearswithhapten,withorwithoutplateletdepletion,byadministeringantiplateletantibodyorbusulfan.Earthickness,leuk...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期TheRegulatorofGProteinSignalingDomainofAxinSelectivelyInteractswithG12butNotG13
【关键词】RegulatorAxin,anegativeregulatoroftheWntsignalingpathway,containsacanonicalregulatorofGproteinsignaling(RGS)coredomain.Herein,wedemonstratebothinvitroandincellsthatthisdomaininteractswiththesubunitoftheheterotrimericGproteinG12butnotwiththecloselyrelatedG13orwithseveralotherheterotrim...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期Long-termeffectofvaryingthesourceoramountofdietarycarbohydrateonpostprandialplasmaglucose,insulin,triacylglycerol,andfreefattyacidconcent
...tineMehling1FromtheDepartmentofNutritionalSciences,FacultyofMedicine,UniversityofToronto,andtheClinicalNutritionandRiskFactorModificationCentre,StMichaelsHospital,Toronto.2SupportedbytheCanadianDiabetesAssociationandtheInternationalOliveOilCouncil.3Reprintsnotavailable.AddresscorrespondencetoT...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第3期Tuberoussclerosis-2tumorsuppressormodulatesERKandB-Rafactivityintransformedrenalepithelialcells
【摘要】Thetuberoussclerosis-2(Tsc-2)geneisasuppressorofrenaltumorigenesisandanearlytargetofreactiveoxygenspecies-inducedrenalcancer.Tuberin,theproteinproductoftheTsc-2gene,participatesintheregulationofcellproliferation,althoughthemechanismbywhichitsuppressesproliferationisunknown.Quinol-thioeth...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第2期Tcell–inducedhyaluronanproductionbyepithelialcellsregulatesinflammation
...ellsmustinfiltrateintothedamagedtissuetoorchestratewoundclosure.Hyaluronanisinvolvedintheinflammationassociatedwithwoundrepairandbindsthesurfaceofleukocytesinfiltratingdamagedsites.SkinTcellsplayspecializedrolesinkeratinocyteproliferationduringwoundrepair.Here,weshowthatTcellsarerequiredforhyalurona...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期S-NitrosylatingAgents:ANovelClassofCompoundsThatIncreaseCysticFibrosisTransmembraneConductanceRegulatorExpressionandMaturationinEpithelialC
...atingTheendogenousbronchodilator,S-nitrosoglutathione(GSNO),increasesexpression,maturation,andfunctionofboththewild-typeandtheF508mutantofthecysticfibrosistransmembraneconductanceregulatoryprotein(CFTR).Thoughtranscriptionalmechanismsofactionhavebeenidentified,GSNOseemsalsotohavepost-transcriptional...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期UrineconcentratingdefectinprostaglandinEP1-deficientmice
...theroleoftheprostaglandinE2(PGE2)EP1receptorinmodulatingurineconcentrationasitisexpressedalongtherenalcollectingductwherearginine-vasopressin(AVP)exertsitsanti-diureticactivity,andintheparaventricularandsupraopticnucleiofthehypothalamuswhereAVPissynthesized.TheurineosmolalityofEP1-nullmice(EP1-/-)fa...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期SelectivegrowthofmucolyticbacteriaincludingClostridiumperfringensinaneonatalpigletmodeloftotalparenteralnutrition
...eshanieGanessunker,SharonMDonovan,RoderickIMackieandHRexGaskins1FromtheDivisionofNutritionalSciences(BD,DG,SMD,RIM,andHRG),andtheDepartmentsofAnimalSciences(OV,RIM,andHRG),VeterinaryPathobiology(HRG),andFoodScienceandHumanNutrition(SMD),UniversityofIllinoisatUrbana-Champaign.2SupportedinpartbyUSDAAg...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第5期