FurincleavageactivatestheepithelialNa+channelbyrelievingNa+self-inhibition
...sreferredtoasNa+self-inhibition.Wepreviouslydemonstratedthatmutationofkeyresidueswithintwofurincleavageconsensussitesin,oronesitein,blockedsubunitproteolysisandinhibitedchannelactivitywhenmutantchannelswereexpressedinXenopuslaevisoocytes(HugheyRP,BrunsJB,KinloughCL,HarkleroadKL,TongQ,CarattinoMD,Joh...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第6期GeneticPathwaystoPrimaryandSecondaryGlioblastoma
...idlydenovo,withoutclinicalorhistologicalevidenceofalessmalignantprecursorlesion.Theyaffectmainlytheelderlyandaregeneticallycharacterizedbylossofheterozygosity10q(70%ofcases),EGFRamplification(36%),p16INK4adeletion(31%),andPTENmutations(25%).Secondaryglioblastomasdevelopthroughprogressionfromlow-grad...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期GlycosylationoftheosmoresponsivetransientreceptorpotentialchannelTRPV4onAsn-651influencesmembranetrafficking
...sensusN-linkedglycosylationmotifwithinthepore-formingloopbetweenthefifthandsixthtransmembranesegmentsoftheosmoresponsivetransientreceptorpotential(TRP)channelTRPV4.MutationofthisresiduefromAsntoGln(i.e.,TRPV4N651Q)resultedinlossofaslowermigratingbandonanti-TRPV4immunoblotsandamarkedreductioninlectin...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期EnhancedCa2+responsetoAVPinpreglomerularvesselsfromratswithgenetichypertensionduringdifferenthydrationstates
【关键词】arterioleRenalResearchGroup,InstituteofMedicine,UniversityofBergenandDepartmentofMedicine,HaukelandUniversityHospital,Bergen,NorwayDepartmentofCellandMolecularPhysiology,UniversityofNorthCarolinaatChapelHill,ChapelHill,NorthCarolinaABSTRACTExaggeratedargininevasopressin(AVP)-inducedca...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第6期TheMethylTransferasePRMT1FunctionsasCo-ActivatorofFarnesoidXReceptor(FXR)/9-cisRetinoidXReceptorandRegulatesTranscriptionofFXRResponsiveG
...iMedicinaClinicaeSperimentale,ClinicadiGastroenterologiaedEpatologia,Universite?degliStudidiPerugia,PoliclinicoMonteluceViaE.DalPozzo,Perugia,Italy(G.R.,B.R.,E.A.,S.F.)DipartimentodiMedicinaClinicaeSperimentale,LabBiologiaMolecolare,Universite?degliStudidiPerugia,PoliclinicoMonteluceViaBrunamonti,Pe...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期Nutritionalassociationswithbonelossduringthemenopausaltransition:evidenceofabeneficialeffectofcalcium,alcohol,andfruitandvegetablenutrien
...ndTherapeutics(HMM,MHNG,andDMR)andtheHealthServicesResearchUnit(MKC),UniversityofAberdeen,UnitedKingdom,andtheCentreforNutritionandFoodSafety,SchoolofBiomedicalandLifeSciences,UniversityofSurrey,Guildford,UnitedKingdom(SAN).2Anyviewsexpressedaretheauthors‘own.3SupportedbytheNutritionResearchProgra...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第1期BoneMorphogeneticProtein-InhibitorGremlinIsOverexpressedinIdiopathicPulmonaryFibrosis
【摘要】Idiopathicpulmonaryfibrosis(IPF),ie,usualinterstitialpneumoniainhistopathology,isadiseasecharacterizedbytissuedestructionandactiveareasoffibroproliferationinthelung.Gremlin(Drm),amemberofthecysteineknotfamilyofbonemorphogeneticprotein(BMP)inhibitors,functionstoantagonizeBMP-4-mediatedsig...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期Highintakesofvegetables,berries,andapplescombinedwithahighintakeoflinoleicoroleicacidonlyslightlyaffectmarkersoflipidperoxidationandl
...ainen,SamarBasu,IrisErlund,IrmaSalminen,AnttiAroandMarjaMutanen1FromtheDivisionofNutrition,UniversityofHelsinki(RFandMM);theBiomarkerLaboratory(GAIE,IS,andAA)andtheDepartmentofMolecularMedicine(MJ),NationalPublicHealthInstitute,Helsinki;andtheSectionofGeriatrics,FacultyofMedicine,UppsalaUniversity,U...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第5期VasopressininducesexpressionoftheCl-/HCO3-exchangerSLC26A7inkidneymedullarycollectingductsofBrattlebororats
...collectingduct(OMCD).ThepurposeofthepresentexperimentswastoexaminetheexpressionofSLC26A7inkidneysofvasopressin-deficientBrattlebororatsbeforeandaftertreatmentwithdesamino-Cys1,D-Arg8-vasopressin(dDAVP).BrattlebororatsweretreatedwithdDAVP,avasopressinanalog,for8days,andtheirkidneyswereexaminedforthee...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期Afuranocoumarin-freegrapefruitjuiceestablishesfuranocoumarinsasthemediatorsofthegrapefruitjuicefelodipineinteraction
...rlyLBeavers,AnneBCriss,SherriSBrown,BrianFThomasandPaulBWatkins1FromtheDivisionofPharmacotherapyandExperimentalTherapeutics(MFPandPBW),theGeneralClinicalResearchCenter(MFP,HLH,SNP,ABC,andPBW),andtheDepartmentofMedicine(KLBandPBW),UniversityofNorthCarolina,ChapelHill,NC;theCitrusandSubtropicalProduct...
医源资料库;在线期刊;美国临床营养学杂志;2006年83卷第5期