AMDaNovelCXCRReceptorAntagonistAbrogatesSchistosomalAntigen-Elicited(Type-)PulmonaryGranulomaFormation
...rableatordersofmagnitude.Forthisstudy,wemeasuredthemRNAexpressionlevelsofCXCR3,CXCR4,CCL2,CXCL12,IL-4,IL-5,andinterferon-.StatisticsTheStudent??st-testwasusedforcomparisonofAMD-treatedandPBScontrolgroups.ValuesofPgreaterthanorequalto0.05wereconsideredtoindicatelackofstatisticalsignificance.Statistic...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期OncogenicAKAP9-BRAFfusionisanovelmechanismofMAPKpathwayactivationinthyroidcancer
...CR1andCR2,thatmediateautoinhibitionofBRAFandaC-terminalproteinkinasedomain(CR3).CR1includestheRAS-GTPbindingdomain(RBD),whichmediatesRASbinding,triggeringtherecruitmentoftheproteintothecellmembraneandkinaseactivation(25).BasedonthecDNAsequence,theAKAP9-BRAFfusionproteinispredictedtolacktheBRAFN-term...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第1期E-andP-SelectinsSynergisticallyInhibitBleomycin-InducedPulmonaryFibrosis
...aredwithwild-typemice.Moreover,themajorityofNKTcellsexpressedhighlevelsofCXCR3,suggestingthatNKTcellinfiltrationisalsodependentonCXCR3expression.TheseresultssuggestthatE-andP-selectinssynergisticallyinhibitlungfibrosisbypromotingtherecruitmentofNKTcells.----------------------------------------------...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期EosinophilsandCCRRegulateInterleukin-Transgene-InducedPulmonaryRemodeling
...tineosinophilchemoattractantmolecules(eotaxin-1,eotaxin-2,andtheirreceptorCCR3)andwithmicegeneticallydeficientineosinophils(dbl-GATA).Wereportthatintheabsenceofeotaxin-2orCCR3,therewasaprofoundreductioninIL-13-inducedeosinophilrecruitmentintothelunglumen.Incontrast,intheabsenceofeotaxin-1,therewasaf...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期Adhesivemechanismsgoverninginterferon-producingcellrecruitmentintolymphnodes
...sorelies,inpart,ontheinteractionbetweenCCR7andthesechemokines.Incontrast,CXCR3andCCR5arepreferentiallyexpressedonTcellsubsetsthatarerecruitedtositesofinflammation,andligandsforthesereceptorsareknowntobeproducedinPLNsinresponsetospecificantigenicstimuli(25,26).IPCsexpressseveraladhesionmoleculesandch...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第5期Neuronaleotaxinandtheeffectsofccr3antagonistonairwayhyperreactivityandM2receptordysfunction
...vagallymediatedbronchoconstriction.WetestedwhetherGW701897B,anantagonistofCCR3(thereceptorforeotaxinaswellasagroupofeosinophilactivechemokines),affectedvagalreactivityandM2Rfunctioninovalbumin-challengedguineapigs.SensitizedanimalsweretreatedwiththeCCR3antagonistbeforeinhalingovalbumin.Antigen-chall...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期LymphocyteFunction-AssociatedAntigen--DependentInhibitionofCornealWoundHealing
...oftoxicoxygenfromhumanphagocytes.JExpMed1983,158:2016-2023RossGD,VetvickaV:CR3(CD11b,CD18):aphagocyteandNKcellmembranereceptorwithmultipleligandspecificitiesandfunctions.ClinExpImmunol1993,92:181-184vanSprielAB,LeusenJH,vanEgmondM,DijkmanHB,AssmannKJ,MayadasTN,vandeWinkelJG:Mac-1(CD11b/CD18)isessent...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期AnovelchemokinereceptorforSDF-1andI-TACinvolvedincellsurvival,celladhesion,andtumordevelopment
...llastwootherchemokines,Mig(CXCL9)andIP10(CXCL10),hadbeenthoughttobindonlyCXCR3(18,19).However,theMCF-7cellsusedinthesestudiesexpressedneitherCXCR3proteinnormRNA(unpublisheddata).Furthermore,IP10andMighadnoinhibitoryeffectonthebindingof125ISDF-1or125II-TACtotheMCF-7cells(unpublisheddata).Like125ISDF-...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期Eosinophiladhesionunderflowconditionsactivatesmechanosensitivesignalingpathwaysinhumanendothelialcells
...teasaresultofinteractionsbetweeneotaxin-3expressedbytheendothelialcellsandCCR3expressedontheeosinophils(4).WeusedaneosinophiliccelllinethatlacksCCR3todifferentiatebetweentheeffectsofbindingundershearstressandtheeffectsoftransmigration.Eosinophilic3D10cellsrollandadheretoIL-4–stimulatedendothelialc...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第6期TheRoleofComplementinInflammatoryDiseasesFromBehindtheScenesintotheSpotlight
...epositedontheendothelialsurface,actsasaligandforß2integrinCD11b/CD18(CR3).Thisadhesionmoleculeisup-regulatedinactivatedleukocytesandcontributestotheaccumulationofthesecellsintheextravascularcompartment.Thedepositionofseveralcomplementproteinsonthesurfaceofendotheliumultimatelyleadstotheformati...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期