MicroparticlesofHumanAtheroscleroticPlaquesEnhancetheSheddingoftheTumorNecrosisFactor-ConvertingEnzyme/ADAMSubstratesTumorNecrosisFactorand
...pressthemetalloproteasetumornecrosisfactor(TNF)-convertingenzyme(TACE/ADAM-17),whichcleavesseveraltransmembraneproteinsincludingTNFanditsreceptors(TNFR-1andTNFR-2).Plaquesalsoharborsubmicronvesicles(microparticles,MPs)releasedfromplasmamembranesaftercellactivationorapoptosis.Wesoughttoexaminewhether...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期Liveattenuatedyellowfever17DinfectshumanDCsandallowsforpresentationofendogenousandrecombinantTcellepitopes
...lasantéetdelarecherchemédicale,Avenir,75015Paris,FranceTheyellowfever(YF)17Dvaccineisoneofthemostsuccessfulliveattenuatedvaccinesavailable.Asingleimmunizationinducesbothlong-lastingneutralizingantibodyandYF-specificTcellresponses.Surprisingly,themechanismforthisrobustimmunityhasnotbeenaddressed.In...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第9期Theroleofangiotensinconvertingenzyme2inthegenerationofangiotensin1
...andANG19.TheACE2inhibitorDX600completelyblockedANGI-mediatedgenerationofANG17.IncubationofPSTswithANG19alsoledtogenerationofANG17,aneffectblockedbytheACEinhibitorcaptoprilorenalaprilat,butnotbyDX600.IncubationofPSTswithANGIIorluminalperfusionofANGIIdidnotresultindetectionofANG17.Theresultsindicateth...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第2期DivergentrolesofIL-23andIL-12inhostdefenseagainstKlebsiellapneumoniae
...ibitsauniquep19subunitsimilartoIL-12p35.IL-12/23p40,interferon(IFN-),andIL-17arecriticalforhostdefenseagainstKlebsiellapneumoniae.Invitro,K.pneumoniae–pulseddendriticcellculturesupernatantselicitTcellIL-17productioninaIL-23–dependentmanner.However,theimportanceofIL-23duringinvivopulmonarychallen...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第6期上海学者《NatureMedicine》发表Th17研究新进展
...葛兰素史克研究中心与美国Baylor医学院的科学家最近在Th17的研究方面取得新的进展,相关成果文章Crucialroleofinterleukin-7inThelpertype17survivalandexpansioninautoimmunedisease公布在最新一期的《NatureMedicine》上。文章通讯作者是来自上海葛兰...
行业资讯;临床快报;细胞分子与蛋白质组AmolecularchaperoneformitochondrialcomplexIassemblyismutatedinaprogressiveencephalopathy
...withoutacomplexItogeneratecandidateassemblyfactors,weidentifiedaparalogue(B17.2L)oftheB17.2structuralsubunit.WefoundanullmutationinB17.2LinapatientwithaprogressiveencephalopathyandshowedthattheassociatedcomplexIassemblydefectcouldbecompletelyrescuedbyretroviralexpressionofB17.2Linpatientfibroblasts....
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期HelperTcelldifferentiationentersanewera:LeRoiestmort;viveleRoi!
...ismuchmorecomplexandinteresting.ThenewestThcellsubsetproducesthecytokineIL-17.NewevidenceshowsthattheIL-17–relatedcytokineIL-25isessentialforTh2responsesintwoinfectiousdiseasemodels.Inthiscommentary,wewillconsiderthenewinformationpertainingtoIL-25inthecontextoftheemergingunderstandingoftheregulati...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期PioglitazoneInhibitsAndrogenProductioninNCI-H295RCellsbyRegulatingGeneExpressionofCYP17andHSD3B2
...changedthesteroidprofileoftheNCI-H295RcellsandinhibitedtheactivitiesofP450c17and3HSDII,keyenzymesofandrogenbiosynthesis.PioglitazonebutnotrosiglitazoneinhibitedtheexpressionoftheCYP17andHSD3B2genes.Likewise,pioglitazonerepressedbasaland8-bromo-cAMP-stimulatedactivitiesofCYP17andHSD3B2promoterreporte...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期Dopuin/Cox17p:一种新的生物能量调节活性肽*
【摘要】Dopuin/Cox17p是新近从酵母和猪小肠中发现和鉴定的一种生物活性肽,分子量8057D左右,加工成熟的活性形式由62个氨基酸残基组成。从DNA和蛋白质数据库中发现,动物中的疟原虫、疟蚊、果蝇和鲨、蛇,以及植物中的拟南...
医源资料库;在线期刊;中华现代中西医杂志;2007年第5卷第2期上海巴斯德所等发现去泛素化酶USP4介导的Th17细胞功能调节新通路
去泛素化酶USP4抑制剂阻止人源Th17分化及功能。A.USP4在Th17细胞中高表达;BC.USP4抑制剂下调Th17细胞中RORγt和IL-17的表达。3月27日,美国免疫学家学会会刊《免疫学杂志》(JournalofImmunology)在线发表了中国科学院上海巴斯德研究所...
医药经济;生物技术;技术要闻