ImpairedearlyBcelltoleranceinpatientswithrheumatoidarthritis
...ularImmunology,HospitalforSpecialSurgery2WeillMedicalCollegeofCornellUniversity,NewYork,NY10021Autoantibodyproductionisacharacteristicofmostautoimmunediseasesincludingrheumatoidarthritis(RA).TheroleoftheseautoantibodiesinthepathogenesisofRAremainselusive,buttheyappearintheserummanyyearsbeforetheonse...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第10期BasolateralP2X4-likereceptorsregulatetheextracellularATP-stimulatedepithelialNa+channelactivityinrenalepithelia
...elocationofthesereceptors,ATPeitherinhibitsorstimulatessodiumreabsorption.UsingA6cells,transepithelialelectricalresistancemeasurements,andscanningionconductancemicroscopy,wehaveidentifiedthepurinergicreceptorsinvolvedinthestimulatoryactionontheepithelialcellbasolateralplasmamembrane.Additionofthepot...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第6期ExpressionofPaxinHumanRenalTumor-DerivedEndothelialCellsSustainsApoptosisResistanceandAngiogenesis
...ormalendothelialcells,expressedPax2proteinandmRNA.Todown-regulatePax2expression,wetransfectedtumor-derivedendothelialcellswithananti-sensePAX2vectorwhereaswetransfectednormalhumanmicrovascularendothelialcellswithasensePAX2vectortoinducePax2expression.TheinhibitionofPax2expressionintumor-derivedendot...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第2期Mechanismunderlyingflowstimulationofsodiumabsorptioninthemammaliancollectingduct
【摘要】VectorialNa+absorptionacrossthealdosterone-sensitivedistalnephronplaysakeyroleintheregulationofextracellularfluidvolumeandbloodpressure.Withinthisnephronsegment,Na+diffusesfromtheurinaryfluidintoprincipalcellsthroughanapical,amiloride-sensitive,epithelialNa+channel(ENaC),whichisconsidere...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第9期EnhancementofHippocampalPyramidalCellExcitabilitybytheNovelSelectiveSlow-AfterhyperpolarizationChannelBlocker3-(Triphenylmethylaminomethyl)pyridi
...yridine(UCL2077),anovelcompound,suppressedthesAHPpresentinhippocampalneuronsinculture(IC50=0.5µM)andintheslicepreparation(IC5010µM).UCL2077wasselective,havingminimaleffectsonCa2+channels,actionpotentials,inputresistanceandthemediumafterhyperpolarization.UCL2077alsohadlittleeffectonhetero...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期NationalInstituteofNeurologicalDisordersandStroke–CanadianStrokeNetworkVascularCognitiveImpairmentHarmonizationStandards
theLondonHealthSciencesCentre(V.H.),UniversityCampus,London,Ontario,CanadatheDepartmentofNeurologyandNeuroscience(C.I.),DivisionofNeurobiology,WeillCornellMedicalCollege,NewYork,NYtheDepartmentofNeurology(R.C.P.),MayoClinic,Rochester,MNtheDepartmentofEpidemiologyandBiostatistics(M.M.B.),ErasmusMedic...
医源资料库;在线期刊;中风学杂志;2006年第37卷第9期InfluenceofEndothelialCellsonVascularSmoothMuscleCellsPhenotypeafterIrradiation
【摘要】Damagetovesselsisoneofthemostcommoneffectsoftherapeuticirradiationonnormaltissues.Weundertookastudyinpatientstreatedwithpreoperativeradiotherapyanddemonstratedinvivotheimportanceofproliferation,migration,andfibrogenicphenotypeofvascularsmoothmusclecells(VSMCs)inradiation-inducedvasculard...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期GProtein-CoupledReceptor0-DependentProteinKinaseAPathwayIsCriticalinNongenomicEffectsofEstrogeninAttenuatingLiverInjuryafterTrauma-Hemorrh
...30(GPR30),hasbeensuggestedasacandidatefortriggeringabroadrangeofE2-mediatedsignaling.GPR30alsoactsindependentlyoftheERtopromoteactivationoftheproteinkinaseA(PKA)pathway,whichprotectscellsfromapoptosisthroughBcl-2.Inthisstudy,weexaminedwhetherthesalutaryeffectsofE2inattenuatinghepaticinjuryaftertraum...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期AdenylylCyclase6OverexpressionDecreasesthePermeabilityofEndothelialMonolayersviaPreferentialEnhancementofProstacyclinReceptorFunction
【关键词】OverexpressionOverexpressionofadenylylcyclase(AC)hasbeenproposedasapotentialgenetherapystrategytoincreasecAMPformationincardiomyocytesandcardiacfunctioninvivo.TheimpactofACoverexpressiononendothelialcells,whichwillbetraversedbygenesdeliveredinvivo,hasnotbeenexamined.Hence,thegoalofthe...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期NegativeRegulationofMyofibroblastDifferentiationbyPTEN(PhosphataseandTensinHomologDeletedonChromosome10)
DivisionofPulmonaryandCriticalCareMedicineandDepartmentofPathology,UniversityofMichiganMedicalSchool,AnnArbor,MichiganUniversityHealthNetwork,OntarioCancerInstitute,UniversityofToronto,Toronto,Ontario,CanadaDivisionofCardiology,DukeUniversityMedicalCenter,Durham,NorthCarolinaABSTRACTRationale:Myofib...
医源资料库;在线期刊;美国呼吸和危急护理医学;2006年第173卷第1期