ThecoffeediterpenecafestolincreasesplasmatriacylglycerolbyincreasingtheproductionrateoflargeVLDLapolipoproteinBinhealthynormolipidemicsubj
...f,DorothyBedford,PierreNMDemacker,MartijnBKatanandChrisJPackard1FromtheDivisionofHumanNutritionandEpidemiology,WageningenUniversity,Wageningen,Netherlands;theDepartmentofPathologicalBiochemistry,GlasgowRoyalInfirmary,Glasgow,UnitedKingdom;andtheDivisionofInternalMedicine,UniversityHospitalNijmegen,N...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第1期Macrophageβ3IntegrinSuppressesHyperlipidemia-InducedInflammationbyModulatingTNFExpression
...dhyperlipidemiaareassociatedwithchronicinflammatorydiseaseslikeatherosclerosis.Integrins,heterodimericmediatorsofinflammatorycellrecruitment,arenotgenerallythoughttobeaffectedbydiet.However,high-fatfeedingpromotesinflammation,atherosclerosis,anddeathinhyperlipidemicmicewithβ3integrindeficiency,...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第12期Dynamicsofaquaporin-2serine-261phosphorylationinresponsetoshort-termvasopressintreatmentincollectingduct
【摘要】Werecentlyidentifiedanovelphosphorylationsite,serine-261(pS261),intheCOOH-terminusofthevasopressin-regulatedwaterchannel,aquaporin-2(AQP2).Toaddresswhetherphosphorylationatthissiteisregulatedbyvasopressin,arabbitpolyclonalphospho-specificantibodywasgenerated.Dotblotandimmunoblotanalysisd...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期TLR9/MyD88signalingisrequiredforclassswitchingtopathogenicIgG2aand2bautoantibodiesinSLE
1LaboratoryofMolecularGeneticsandImmunology,TheRockefellerUniversity,NewYork,NY100212TheInstituteforSystemsBiology,Seattle,WA98103Lossoftoleranceinsystemiclupuserythematosus(SLE)leadstothegenerationofautoantibodies,whichaccumulateinend-organswheretheyinducedisease.Hereweshowthatimmunoglobulin(Ig)G2a...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期Predictorsofpostprandialtriacylglycerolresponseinchildren:theColumbiaUniversityBiomarkersStudy
SarahCCouch,CarmenRIsasi,WahidaKarmally,WilliamSBlaner,ThomasJStarc,DoritKaluski,RichardJDeckelbaum,HenryNGinsberg,StevenSheaandLarsBerglund1FromtheDepartmentsofPediatricsandMedicine,ColumbiaUniversity,NewYork.2SupportedbygrantsHD32195,HL56984,andRR00645fromtheNationalInstitutesofHealth,Bethesda,MD....
医源资料库;在线期刊;美国临床营养学杂志;2000年72卷第5期ANaphthoquinoneDerivative,Shikonin,HasInsulin-LikeActionsbyInhibitingBothPhosphataseandTensinHomologDeletedonChromosome10andTyrosinePhosph
...toincreaseglucoseuptakebyadipocytesandmyocyteswithminoreffectsonproteintyrosinephosphorylationinthecells(BiochemBiophysResCommun292:642-651,2002).Thepresentstudywasperformedtoexaminethemechanismofthisactionofshikonin.Shikonininhibitedthephosphatidylinositol3,4,5-triphosphate(PtdIns-3,4,5-P3)phosphat...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期MultilocusSequenceTypingofNeisseriameningitidisDirectlyfromClinicalSamplesandApplicationoftheMethodtotheInvestigationofMeningococcalDiseas
...atory,BirminghamDepartmentofBiologicalSciences,ManchesterMetropolitanUniversity,Manchester,UnitedKingdomABSTRACTInfectionsassociatedwithNeisseriameningitidisareamajorpublichealthprobleminEngland,Wales,andNorthernIreland.Currently,over40%ofcasesareconfirmeddirectlyfromclinicalspecimensusingPCR-basedm...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期MutationofthephospholipaseC-1–bindingsiteofLATaffectsbothpositiveandnegativethymocyteselection
...dHealthandHumanDevelopment,NationalInstitutesofHealth,Bethesda,MD208923DivisionofTherapeuticProteins,CenterforBiologicsEvaluationandResearch,FoodandDrugAdministration,Bethesda,MD20892LinkerforactivationofTcells(LAT)isascaffoldingadaptorproteinthatiscriticalforTcelldevelopmentandfunction.AmutationofL...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第7期Gq-dependentsignalingcascadesstimulatewater-seekingbehavior
....Additionalstudiesrevealedasecondphenotypecharacterizedbypolyuriaandpolydipsia.Thepolyuricphenotypewasnotcausedbyabnormalglucosemetabolismorhypercalcemiabutwasaccompaniedbyreducedurinaryconcentratingability.Additionalstudiesfoundthat1)waterrestrictionwasassociatedwithanappropriateincreaseinserumvaso...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第10期IdentificationandlocalizationofTRPCchannelsintheratkidney
【摘要】Itiswellestablishedthattransientreceptorpotential(TRP)channelsareactivatedfollowingstimulationofGprotein-coupledmembranereceptorslinkedtoPLC,buttheirdifferentialexpressioninvariouscellsoftherenalnephronhasnotbeendescribed.Inthepresentstudy,immunoprecipitationsfromratkidneylysatesfollowed...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期