AntieosinophilicActivityofOrazipone
...-reactivecompoundthathasbeenpreviouslyshowntoreducelungeosinophiliainguineapigsandratsandtoinhibitdegranulationinmastcellsandcytokineproductioninmonocytesandT-cells.However,theeffectsoforaziponeongranulocytelongevityareunknown.Oraziponeanditsderivative3-(4-chloro-3-nitro-benzylidene)-pentane-2,4-dio...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期PTEN与妇科肿瘤
...白磷酸酶活性,通过这两种活性和负性调控三条途径[1,2](PI3K/AKT/PKB信号传导通路;焦点粘附激酶,FAK途径;细胞分裂素激活的蛋白激酶,MAPK途径)来调节细胞的生长、增殖、分化、凋亡、粘附、迁移和血管生长等,在维持细胞的增殖、...
医源资料库;在线期刊;中华医学实践杂志;2010年第9卷第1期IncreasedInsulin-StimulatedExpressionofArterialAngiotensinogenandAngiotensinType1ReceptorinPatientsWithType2DiabetesMellitusandAtheroma
...CE)andAT1receptor(AT1R)weredeterminedincarotidatheromaplaque,nearbymacroscopicallyintacttissue(MIT),andinvascularsmoothmusclecells(VSMCs)beforeandafterinsulinstimulationfrom21T2Dand22CTRpatients.AGTandACEmRNAandtheirproteinlevelswere2-to3-foldhigherinatheromaandinMITofT2Dpatients.VSMCsfromT2Dpatient...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第3期与CD28有关的协同刺激信号转导
...关注[4]。Tyr170磷酸化后,可招募含SH-2的信号分子,如PI3-K。后者曾一度成为CD28转导的协同刺激信号途径中的研究热点[5~7,8]。详见下文。Tyr185,197至今未有证据表明它们参与CD28信号转导[7]。近年来有实验表明Tyr188的...
合作平台;在线期刊;中华现代临床医学杂志;2004年第2卷第3A期ConnectiveTissueGrowthFactorInducesExtracellularMatrixinAsthmaticAirwaySmoothMuscle
RespiratoryResearchGroup,DepartmentofPharmacology,andDisciplineofMedicine,TheUniversityofSydneyWoolcockInstituteforMedicalResearch,RoyalPrinceAlfredHospitalDepartmentofEndocrinology,RoyalPrinceAlfredHospital,Sydney,AustraliaABSTRACTTransforminggrowthfactor(TGF)-andconnectivetissuegrowthfactormaybeim...
医源资料库;在线期刊;美国呼吸和危急护理医学;2006年第173卷第1期Randomisedclinicaltrialoftheeffectivenessofbase-inprismreadingglassesversusplaceboreadingglassesforsymptomaticconvergenceinsufficiencyinch
...ntrolgroup,norandomisation,andnon-maskedoutcomeexaminations.14–16Thus,inspiteofthecommonuseandratherbroadacceptanceofbase-inprismforthetreatmentofCI,thereislittlescientificevidenceshowingitseffectiveness.Thisprospectiverandomised,doubleblind,placebocontrolledclinicaltrialwasdesignedtoevaluatetheef...
医源资料库;在线期刊;英国眼科学杂志;2005年第89卷第10期Low-DoseBBR3610ToxicityinColonCancerCellsIsp53-IndependentandEnhancedbyInhibitionofEpidermalGrowthFactorReceptor(ERBB1)-PhosphatidylInosito
...lls,andwasenhancedinK-RASD13nullcells.Smallmoleculeormolecularinhibitionofepidermalgrowthfactorreceptor(ERBB1)orphosphatidylinositol3kinase(PI3K)enhancedBBR3610toxicityinHCT116,DLD1,andSW480cells.Smallmoleculeormolecularinhibitionofcaspase8functionabolishedthetoxicityofBBR3610andofBBR3610+ERBB1inhib...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第9期AktIsEssentialforInsulinModulationofAmphetamine-InducedHumanDopamineTransporterCell-SurfaceRedistribution
...thatinsulinanditssubsequentsignalingthroughthephosphatidylinositol3-kinase(PI3K)-dependentpathwayopposethiseffectofAMPHbypromotingincreasedcell-surfaceexpression.Here,weusedhumanembryonickidney293cellsstablyexpressingthehumanDAT(hDATcells)toinvestigatethedownstreamcellularcomponentsimportantforthise...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第1期RegulationofanaphylacticresponsesbyphosphatidylinositolphosphatekinasetypeI
...harmacology,StateUniversityofNewYork,StonyBrook,NY11794Themembranephospholipidphosphatidylinositol4,5-bisphosphate[PI(4,5)P2]isacriticalsignaltransducerineukaryoticcells.However,thephysiologicalrolesofthetypeIphosphatidylinositolphosphatekinases(PIPKIs)thatsynthesizePI(4,5)P2arelargelyunknown.Here,w...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期一种重离子辐照诱发细胞内染色体断裂的理论计算方法*
...后平均每细胞内染色体断裂的产额可以表示为:N=F×π24Numbercells(3)1.2细胞培养及辐照人正常肝细胞系L02(购自CCTCC)用含有10%胎牛血清的RMPI-1640培养液在37℃,5%CO2的恒温培养箱内培养,培养基内另加入胰岛素0.25U/ml。细...
医源资料库;在线期刊;中华实用医药杂志;2007年第7卷第13期