人工假体周围骨溶解的基因治疗研究进展
...面取得了一定的进展,甚至有些基因治疗方案显示了临床试验计划,但目前所进行的工作绝大多数尚处于实验阶段,许多关键性的技术和理论仍有待进一步深入研究。比如说如何开发更多的真正确实有效的目的基因,如何构建安...
医源资料库;在线期刊;中国矫形外科杂志;2006年第14卷第9期SynthesisoftheNa-K-ATPase-subunitisregulatedatboththetranscriptionalandtranslationallevelsinIMCD3cells
【关键词】cellsUniversityofColoradoHealthSciencesCenter,DivisionofRenalDiseasesandHypertension,SchoolofMedicine,Denver,ColoradoABSTRACTWepreviouslyreportedthathypertonicity-mediatedupregulationofthe-subunitofNa-K-ATPaseisdependentonboththeJNKandthePI3kinasepathways(ProcNatlAcadSciUSA98:13414,20...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第1期MultiplexPCRforTypingStrainsofToxoplasmagondii
...gongeographicallocation(6).Inimmunocompetentchildrenandadults,theinfectionisusuallyasymptomaticorrevealedin10%ofcasesbycervicaloroccipitallymphadenopathy(14).However,muchlessfrequently,inimmunocompetentindividualssevereacquiredforms,suchaschorioretinitis(3),orpulmonaryforms(4)havealsobeendescribed.W...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期AktIsEssentialforInsulinModulationofAmphetamine-InducedHumanDopamineTransporterCell-SurfaceRedistribution
...chiatryandPharmacology,CenterforMolecularRecognition,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NewYork(J.A.J.)AbstractUptakebythedopaminetransporter(DAT)istheprimarypathwayfortheclearanceofextracellulardopamine(DA)andconsequentlyforregulatingthemagnitudeanddurationofdopaminergicsigna...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第1期Visualmaturationofterminfantsfedlong-chainpolyunsaturatedfattyacidsupplementedorcontrolformulafor12mo
...sternMedicalCenter,Dallas,TX,andINTA,UniversityofChile,Santiago,Chile(RDU)2Supportedbygrantno.HD22380fromtheNationalInstituteofChildHealthandHumanDevelopment.MeadJohnsonNutritionals(Evansville,IN)donatedallinfantformulasforthestudy.3AddressreprintrequeststoEEBirch,RetinaFoundationoftheSouthwest,9900...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第4期ChroniclymphocyticleukemiaBcellscontainanomalousLyntyrosinekinase,aputativecontributiontodefectiveapoptosis
...essedattheproteinlevelinleukemiccellsascomparedwithnormalBlymphocytes,withasubstantialaliquotofthekinaseanomalouslypresentinthecytosol.WhereasinnormalBlymphocytesLynactivationisdependentonBcell–receptorstimulation,inrestingmalignantcells,theconstitutiveactivityofthekinaseaccountsforhighbasalprotei...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期植物雌激素结构类型与资源分布、药理活性和临床应用
...素中,葛雌素和冠狗牙花定具有很强的雌激素作用。小鼠试验表明:葛雌素的活性为17β-雌二醇的1.3倍;皮下注射的作用强度与17β-雌二醇相当,为雌酮的2.2倍;口服给药促进子宫生活为己烯雌酚的3倍。大鼠皮下注射葛雌素,...
药品天地;专业药学;中药大全;中药研究与新药申报VascularEndothelialGrowthFactorReceptor2PlaysaRoleintheActivationofAorticEndothelialCellsbyOxidizedPhospholipids
...sofPAPC(Ox-PAPC)regulatecelltranscriptionofinterleukin-8,LDLreceptor,andtissuefactor.Thisupregulationtakesplaceinpartthroughtheactivationofsterolregulatoryelement-bindingprotein(SREBP)andErk1/2.Thepresentstudiesidentifyvascularendothelialgrowthfactorreceptor2(VEGFR2)asamajorregulatorintheactivationo...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第2期摩挲
摩挲(suō梭) 即推拿。见该条。作者:佚名
医源资料库;中医词典;字母M多靶点酪氨酸激酶抑制剂Sunitinib治疗肾细胞癌有效
...研究结果表明,一种新的小分子抗肿瘤靶向治疗药物——sunitinib(SU11248),在转移性肾细胞癌的二线治疗中显示出显著的疗效。(JClinOncol2006,24(1): Sunitinib属于多靶点的受体酪氨酸激酶抑制剂,对多种蛋白的酪氨酸激酶活性具有抑制...
行业资讯;临床快报;肿瘤相关