GeneticandAntigenicCharacterizationofRotavirusSerotypeG9StrainsIsolatedinAustraliabetween1997and2001
EntericVirusResearchGroup,DepartmentofGastroenterologyandClinicalNutrition,MurdochChildrensResearchInstitute,RoyalChildren‘sHospital,1DepartmentofPaediatrics,UniversityofMelbourne,Melbourne,Victoria,Australia30522Received13January2003/Returnedformodification10May2003/Accepted8June2003 ABSTRACTTo...
医源资料库;在线期刊;微生物临床杂志;2003年第41卷第8期Lightchaineditinggeneratespolyreactiveantibodiesinchronicgraft-versus-hostreaction
1DepartmentofPathology,GwenKnappCenterforLupusandImmunologyResearch,UniversityofChicago,Chicago,IL606372LaboratoryofMolecularGeneticsandImmunology,TheRockefellerUniversity,NewYork,NY10021Thechronicgraft-versus-host(cGvH)reactionisamodelofinducedlupuscausedbyalloreactiveCD4+TcellsfromaBm-12mouseinaC5...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期HJBM:Z-DNA的特点、功能与相关疾病
...螺旋在细胞内也是刺激形成Z-DNA的原因,负超螺旋在生物系统的DNA代谢中很常见,包括复制,转录等。转录时,RNA聚合酶在DNA双链上移动产生负超螺旋,DNA双链解开,从而产生反向扭转力使Z-DNA稳定。而在体内,Z-DNA常需要一些特...
医药经济;生物技术;技术要闻ContributionofDNApolymerasetoimmunoglobulingenehypermutationinthemouse
InstitutNationaldelaSantéetdelaRechercheMedicaleU373,FacultédeMédecineNecker-EnfantsMalades-UniversitéParisV,75730ParisCedex15,FranceThemutationpatternofimmunoglobulingeneswasstudiedinmicedeficientforDNApolymerase,atranslesionalpolymerasewhoseinactivationisresponsibleforthexerodermapigmentosumva...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期DirectcleavageofROCKIIbygranzymeBinducestargetcellmembraneblebbinginacaspase-independentmanner
1InstitutNationaldelaSantéetdelaRechercheMedicale(INSERM)U461,IFR75,FacultédePharmacie,92296Chatenay-Malabry,France2INSERMU517,FacultédeMédecineetdePharmacie,21079Dijon,FranceCaspaseactivationintargetcellsisamajorfunctionofgranzymeB(grB)duringcytotoxiclymphocytegranule-inducedapoptosis.grB-media...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期InducibleDNAbreaksinIgSregionsaredependentonAIDandUNG
DepartmentofMolecularGeneticsandMicrobiology,PrograminImmunologyandVirology,UniversityofMassachusettsMedicalSchool,Worcester,MA01655Classswitchrecombination(CSR)occursbyanintrachromosomaldeletionwherebytheIgMconstantregiongene(Cμ)isreplacedbyadownstreamconstantregiongene.Thisuniquerecombinationeven...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第4期Structure-FunctionAnalysisofVitaminD24-Hydroxylase(CYP24A1)bySite-DirectedMutagenesis:AminoAcidResiduesResponsibleforSpecies-BasedDifferenceo
【关键词】Structure-FunctionOurpreviousstudiesrevealedthespecies-baseddifferenceofCYP24A1-dependentvitaminDmetabolism.AlthoughhumanCYP24A1catalyzesbothC-23andC-24oxidationpathways,ratCYP24A1showsalmostnoC-23oxidationpathway.Wetriedtoidentifyaminoacidresiduesthatcausethespecies-baseddifferenceby...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期ComparisonofemmTypingandRibotypingwithThreeRestrictionEnzymesToCharacterizeClinicalIsolatesofStreptococcuspyogenes
InfectiousDiseasesResearch,AbbottLaboratories,AbbottPark,IllinoisABSTRACTAtotalof336Streptococcuspyogenesisolatesrecentlyrecoveredfrompatientswithpharyngitisfrom13countrieswerecharacterizedbyemmtypingandriboprintingusinganautomatedRiboprinter(Dupont/Qualicon)basedonthepatternsproducedbythreerestrict...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期UseofPCRTargetingofInternalTranscribedSpacerRegionsandSingle-StrandedConformationPolymorphismAnalysisofSequenceVariationinDifferentRegions
FermentationTechnologyDivision,CentralDrugResearchInstitute,Lucknow,IndiaABSTRACTTheincreasedincidenceoffungalinfectionsintherecentpasthasbeenattributedtotheincreaseinthenumberofhumanimmunodeficiencyvirus-positiveandAIDSpatients.Earlydiagnosisofmycosesinpatientsiscrucialforpromptantifungaltherapy.Im...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期AtypicalSerologicalResponseMarkedbyaLackofDetectableAnti-gp43AntibodiesinaPatientwithDisseminatedParacoccidioidomycosis
LaboratoriesofMedicalMycologyDermatologyandImmunodeficienciesImmunopathology,InstituteofTropicalMedicine,MedicalSchooloftheUniversityofSoPaulo,BrazilDivisionofInfectiousandParasiticDiseases,ClinicsHospital,MedicalSchooloftheUniversityofSoPaulo,BrazilABSTRACTSerologicaltestsarefrequentlyusedtodiagnos...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期