Cytokinesignaltransductionissuppressedinpreselectiondouble-positivethymocytesandrestoredbypositiveselection
...ederickCancerResearchandDevelopmentCenter,Frederick,MD21702DeathbyneglectrequiresthatCD4+8+double-positive(DP)thymocytesavoidcytokine-mediatedsurvivalsignals,whichispresumablywhyDPthymocytesnormallyextinguishIL-7Rgeneexpression.WereportthatDPthymocytesbeforepositiveselection(preselectionDPthymocytes...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期RoscovitineTriggersExcitotoxicityinCulturedGranuleNeuronsbyEnhancingGlutamateRelease
...vitineenhancesthecouplingbetweentetrodotoxin-sensitiveactionpotentialsandP/Q-typevoltage-dependentcalciumchannels(VDCCs),therebyconvertingthissurvivalprogramtoexcitotoxicityofsynapticorigin.Therefore,roscovitine-triggerednecrosisrequiresspontaneousNa+-basedactionpotentials(tetrodotoxininhibits,(±)-...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期Small-MoleculeScreenIdentifiesInhibitorsofaHumanIntestinalCalcium-ActivatedChlorideChannel
...tiviralexpressionofayellowfluorescentprotein(YFP)-typehalidesensor(YFP-H148Q/I152L;Jayaramanetal.,2000).AsdiagrammedinFig.1A,thecell-basedassayinvolvedmeasurementofiodideinfluxinamonolayerofYFP-expressingHT-29cellsinresponsetoacombinationofcalcium-elevatingagonists.Acombinationofagonistswasusedtopre...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期Identificationofthetargetself-antigensinreperfusioninjury
...aratmodelofmyocardialinfarctionsuggestedaroleforinnateimmunityinRI(9).Subsequently,Weismanetal.demonstratedthatpretreatmentofratswithaspecificsolubleinhibitorofcomplementC3(sCR1)dramaticallyreducedinjuryinasimilarmodelofmyocardialinfarctionandfurtherestablishedtheimportanceofcomplementasamediatorofi...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期顶羽菊内酯Acroptilin
...,(α)D+92.3°;熔点197~199°,(α)D+100°;NMR((CD32CO)δ:3.90(H-3),4.80(q,J=10.5,9,H-6),5.22(m,H-8),5.70(d,J=3.5,H-13),6.05(d,J=3.5,H-13),5.03,5.21(H-14),3.05,3.15(d,J=5,H-15),3.76,3.96(d,J=11.5,3‘-H2),1.54(s,z‘-CH3)。[成分分类][药理作用]体外实验证明,浓度0.24-7.8μg/ml时对...
药品天地;专业药学;中药大全;中草药有效成分RegulationofperipheralTcellactivationbycalreticulin
...s.Indeed,defectsinnegativeregulatorymolecules,suchasphosphatases(2,3),E3ubiquitinligases(4,5),cellsurfacereceptors(6),andtranscriptionfactors(7,8),contributetothedevelopmentofimmunopathology.Defectsintheinductionofapoptosiswereshowntoaffectthedeletionofautoreactivecellsinthethymus,resultinginautoimm...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期Geneticepidemiologyofdiabetes
...ingpregnancythatusuallysubsidesafterdeliverybuthasmajorimplicationsforsubsequentriskofT2D,aspregnancyservesasan“environmental“stressorthatrevealsageneticpredisposition.Otherlesscommonformsofdiabetesincludetherare,geneticallydetermineddiseasematurityonsetdiabetesoftheyoung(MODY),diabetesresulting...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期芫花根的HNMR指纹图谱解析
...得3个黄色针状晶体(化合物5,6,7)以MS、HNMR、CNMR、H-HCOSY、HSQC和NOESY等光谱学方法鉴定化合物分子结构。1.2.2 不同溶剂分级系统的提取物制备取芫花根150g,其中50g以石油醚-丙酮-甲醇(1∶1∶1)80℃水浴回流1h;50g以氯仿→乙醚→乙酸乙...
药品天地;专业药学;中药大全;中药指纹图谱SingleMutationsatAsn295andLeu305intheCytoplasmicHalfofTransmembrane-HelixDomain7oftheAT1ReceptorInducePromiscuousAgonistSpecificityfor
...UniformedServicesUniversityoftheHealthSciences,Bethesda,Maryland(Y.-H.F.,R.Q.)DepartmentofMedicine,CWRUSchoolofMedicine,Cleveland,Ohio(L.Z.,R.Z.)AbstractThemoststrikingfeatureofaGprotein-coupledreceptor(GPCR)isitshighlyexclusiveagonistspecificity.ThisfeatureguaranteesthataGPCRrecognizesonlyitsspecif...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期AmongBcellnon-Hodgkin‘slymphomas,MALTlymphomasexpressauniqueantibodyrepertoirewithfrequentrheumatoidfactorreactivity
...s)bycomparing,attheaminoacidlevel,theirimmunoglobulin(Ig)VH-CDR3swithCDR3sequencespresentinGenBank.Follicularlymphomas,diffuselargeBcelllymphomas,Burkitt‘slymphomas,andmyelomasexpressedaCDR3repertoirecomparabletothatofnormalBcells.MantlecelllymphomasandBcellchroniclymphocyticleukemias(B-CLLs)expre...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期