AIDfrombonyfishcatalyzesclassswitchrecombination
...whetherevolutionofclassswitchrecombinationrequiredalterationsinAID,weassayedAIDfromJapanesepufferandzebrafishforclass-switchingactivityinmouseBcells.WefindthatfishAIDcatalyzesclassswitchrecombinationinmammalianBcells.Thus,AIDhadthepotentialtocatalyzethisreactionbeforetheteleostandtetrapodlineagesdiv...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第6期生存素与消化道肿瘤关系的研究近况
...义核苷酸可增加胰腺BxPC-3细胞对吉西他滨的化疗敏感性。Dai等[20]研究证明survivin在人肝癌细胞多耐药模型(HepG2/ADM)细胞表达上调与其耐药性密切相关,反义复合物能有效下调survivin表达水平,并且增强耐阿霉素细胞HepG2/ADM对...
医源资料库;在线期刊;中华现代内科学杂志;2007年第4卷第9期Anunfermentedgelcomponentofpsylliumseedhuskpromoteslaxationasalubricantinhumans
....Stoolsandqualitativebowelresponses,foodintake,andactivitydatawerecollecteddailyduringbothweeksofcontrolleddiet.ThestudywasapprovedbytheCollegeofAgriculturalandLifeSciencesHumanSubjectsCommittee,UniversityofWisconsinMadison.DietAllsubjectsconsumedfixeddietsduringthePSHandbasalperiodsthatconsis...
医源资料库;在线期刊;美国临床营养学杂志;2000年72卷第3期DisparaterolesofATRandATMinimmunoglobulinclassswitchrecombinationandsomatichypermutation
...ormutated)fromanabasicsitelocatedonthenontranscribedstrand(42).BecauseATRandAIDcanbothassociatewithRPA,thisraisesseveralpossibleexplanations;ATRcouldbeactingasearlyasattheinitialAIDtargetingstagebyphosphorylatingRPA(50)orbyregulatingitsintranucleartranslocation(51).Alternately,RPArecruitsATR–ATRIP...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期脑肿瘤干细胞起源的研究进展和意义
...胞内的Sonichedgehog(shh)通路,可诱导生成髓母细胞瘤;Dai等[9]将Ras、Akt基因导入神经祖细胞和星形胶质细胞,发现只有转入神经祖细胞才能导致肿瘤产生。有实验表明,转染了致癌基因的神经干细胞在小鼠中长出脑肿瘤,而...
医源资料库;在线期刊;中华现代外科学杂志;2007年第4卷第9期ComparativeAnalysisoftheDiagnosticPerformanceofSixMajorEchinococcusgranulosusAntigensAssessedinaDouble-Blind,RandomizedMulticenterStudy
...ationalCenterGrantTW05718.AdditionalsupportwasalsoprovidedbygrantsAI35894andAI051976fromtheNIH(UnitedStates)andtheRTPDnetworkfundedbytheSwedishInternationalDevelopmentAgency.K.M.M.istherecipientofaPIBIC-CNPq(Brazil)fellowship.ConicetandCabbioyRoemmers(Argentina)arealsoacknowledged.WethankArnaldoZaha...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期Therelationofmagnesiumandcalciumintakesandageneticpolymorphisminthemagnesiumtransportertocolorectalneoplasiarisk
QiDai,MarthaJShrubsole,ReidMNess,DavidSchlundt,QiuyinCai,WalterESmalley,MingLi,YuShyrandWeiZheng1FromtheVanderbiltEpidemiologyCenter(QD,MJS,QC,andWZ)andtheDivisionofGastroenterology,HepatologyandNutrition(RMNandWES),DepartmentofMedicine,andtheDepartmentofBiostatistics(MLandYS),Vanderbilt-IngramCance...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第3期PPARinhibitsvascularsmoothmusclecellproliferationunderlyingintimalhyperplasiabyinducingthetumorsuppressorp16INK4a
...iographyTrial(LOCAT;ref.17),andtheDiabetesAtherosclerosisInterventionStudy(DAIS;ref.17),haverevealedthatfibratesinhibitatheromatousplaqueprogressionviaeffectspossiblyindependentorinadditiontotheirsystemicaction.Theseobservationsareinlinewithresultsfrominvivostudiesperformedinrabbits,whichindicatedth...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第11期MonocyteChemoattractantProtein-1IsanEssentialInflammatoryMediatorinAngiotensinII-InducedProgressionofEstablishedAtherosclerosisinHypercholeste
...,KyushuUniversity,Fukuoka,Japan;andtheNewProductResearchLaboratories(K.N.),Dai-ichiPharmaceuticalCompany,Tokyo,Japan.CorrespondencetoDrKensukeEgashira,DepartmentofCardiovascularMedicine,GraduateSchoolofMedicalSciences,KyushuUniversity,3-1-1,Maidashi,Higashi-ku,Fukuoka812-8582,Japan.E-mailegashira@ca...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第3期幽门螺杆菌IgG抗体胶体金免疫层析快速诊断试纸条的研制
...kitforserumH.pyloriantibodyIgG ZHANGBao-yuan,WANGXiao-wei,CUIXiao-dai,etal.CapitalInstituteofPediatrics,Beijing100020,China 【Abstract】ObjectiveDevelopinggoldimmunochromatographictestkitforserumH.pyloriantibodyIgGandoptimizethekeyexperimentconditions.MethodsPreparingthecolloid...
医源资料库;在线期刊;中华医学研究杂志;2006年第6卷第2期