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Noaudiblewheezing:nuggetsandconundrumsfrommouseasthmamodels
...physiologicallybypersistentAHRtopharmacologicbronchoconstrictors,andbyvariable,episodicintrathoracicairflowobstructionthatisatleastpartlyreversiblewithagonistsofthe2adrenergicreceptor.AsthmaisalsoassociatedwithTh2-likebronchialwallinflammation,regardlessofwhetherindividualshaveallergen-specificIgE.L...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第12期 -
ResponsetoWindahletal.
...letal.(1)withinterest.Whileweagreewiththeconclusionthatestrenmaynotbeasuitableclinicalcandidateforthetreatmentofpostmenopausalosteoporosisduetoeffectsonreproductivetissuesthatwedidnotobserve(2),westronglydisagreewiththeinterpretationoftheevidence.Postmenopausalosteoporosisisadiseaseoflateadulthoodin...
医源资料库；在线期刊；临床研究杂志；2006年第116卷第11期 -
实验性消化道溃疡上皮淋巴细胞毒活性的变化
...。方法：应用生物学测定法检测了水浸限制刺激诱发的C57BL/6小鼠消化道溃疡动物模型肠上皮淋巴细胞和脾淋巴细胞的细胞毒活性的变化。结果：发现给予水浸限制刺激后第2天，小鼠肠上皮淋巴细胞对靶细胞的杀伤活性增至最高...
合作平台；医学论文；临床医学与专科论文；检验医学 -
InVivoX-RayAngiographyintheMouseBrainUsingSynchrotronRadiation
...AthinPE-50tubewasplacedintheunilateralexternalcarotidarteryinadultmaleC57BL/6Jmice.Whilemaintainingthebloodflowintheinternalcarotidartery,33μLofcontrastagentwasinjectedandthenselectiveangiographyofthehemispherewasperformed.Results—Theaveragediametersofcerebralarterywereasfollows:142.5±7.90μminm...
医源资料库；在线期刊；中风学杂志；2006年第37卷第7期 -
GeneticMappinginMiceIdentifiesDMBTasaCandidateModifierofMammaryTumorsandBreastCancerRisk
...orts.Ageneticscreenof176N2backcrossprogenyoftwoTrp53+/Cstrains,BALB/candC57BL/6,whichdifferintheirsusceptibilitytomammarytumors,identifiedamodifierofmammarytumorsusceptibilityinan25-Mbintervalonmousechromosome7(designatedSuprMam1).Relativetoheterozygotes,homozygosityforBALB/callelesofSuprMam1signifi...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第6期 -
ExacerbatedPathologyofViralEncephalitisinMicewithCentralNervousSystem-SpecificAutoantibodies
...------------------------------------------------------------Itisnowwellestablishedinanimalmodelsthatinfectiousorganismscantriggeroraugmentimmuneresponsestoself-antigens,bymechanismssuchasmolecularmimicryorbystanderactivation(seereview1).However,autoimmunitydoesnotalwaysresultinclinicallyapparentdise...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第2期 -
InflammatoryMurineSkinResponsestoUV-BLightArePartiallyDependentonEndothelin-andMastCells
...flammation,ET-1concentrationsincreasedsubstantiallyandcontinually.Moreover,blockingofET-1receptors(ETA)resultedinsignificantlydecreasedcutaneousinflammationfollowingUVirradiation.WhenweassessedskinresponsestoET-1injections,weobservedprominentmastcelldegranulationandmastcell-dependentinflammation.Sin...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第9期 -
SDF-1isbothnecessaryandsufficienttopromoteproliferativeretinopathy
...nter,Gainesville,Florida,USA.AbstractDiabeticretinopathyistheleadingcauseofblindnessinworking-ageadults.Itiscausedbyoxygenstarvationintheretinainducingaberrantformationofbloodvesselsthatdestroyretinalarchitecture.Inhumans,vitrealstromalcell–derivedfactor–1(SDF-1)concentrationincreasesasprolifera...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第1期 -
Lossofreceptor-mediatedlipiduptakeviascavengerreceptorAorCD36pathwaysdoesnotameliorateatherosclerosisinhyperlipidemicmice
...ogenesis.Inthisstudy,Apoe–/–micelackingSR-AorCD36,backcrossedintotheC57BL/6strainfor7generations,werefedanatherogenicdietfor8weeks.HyperlipidemicCd36–/–Apoe–/–andMsr1–/–Apoe–/–miceshowedsignificantreductionsinperitonealmacrophagelipidaccumulationinvivo;however,incontrastwithprevi...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第8期 -
ImmunoprivilegedstatusoftheliveriscontrolledbyToll-likereceptor3signaling
...mviaTLRs(12).RecentlyitwasshownthatactivationofTLR3orTLR7(whichrecognizedouble-strandedandsingle-strandedRNA[dsRNAandssRNA],respectively)promotesautoimmunityinmiceexhibitinghighfrequenciesoffunctionalautoreactiveCD8+Tcells.Diseaseonset/progressioncloselycorrelatedwithIFN-production(13,14),suggesting...
医源资料库；在线期刊；临床研究杂志；2006年第116卷第9期