CodingandNoncodingGenomicRegionsofEntamoebahistolyticaHaveSignificantlyDifferentRatesofSequencePolymorphisms:ImplicationsforEpidemiologicalS
DepartmentofMicrobiologyandImmunologyDepartmentofInternalMedicine,DivisionofInfectiousDiseases,StanfordUniversitySchoolofMedicine,Stanford,California94305-5124CentreforHealthandPopulationResearch,InternationalCentreforDiarrhoealDiseaseResearch,Bangladesh,Dhaka,BangladeshABSTRACTToevaluategeneticvari...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期Nature:CRISPR中Cascade复合物结构
...它的辅助蛋白(CRISPR-associated,Cas)构成CRISPR/Cas系统,以一种类似于真核生物RNA干扰(RNAi)的作用机制,在原核生物抵抗入侵的噬菌体和质粒的防御系统中发挥着重要作用。CRISPR-Cas系统分为三个类型(I型,II型和III型),大肠杆菌C...
医药经济;生物技术;技术要闻5‘-O-TritylatedNucleosideDerivatives:InhibitionofThymidinePhosphorylaseandAngiogenesis
【关键词】5‘-O-TritylatedThymidinephosphorylase(TPase)isoneofthekeyenzymesinvolvedinthepyrimidinenucleosidesalvagepathway.However,TPasealsostimulatesangiogenesis,anditsexpressioncorrelateswellwithmicrovesseldensityandmetastasisinavarietyofhumantumors.Wehaveshownrecentlythat5‘-O-trityl-inosi...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期后磨牙桩核修复技术的实验研究
...estoringtooth;displacement;strain后磨牙是口腔中主要咀嚼器官之一,因磨耗或其他原因而只有残根时,过去一般认为是拔除,但近几年由于治疗手段的科学化和先进化,对后磨牙进行桩核修复已在临床上得到应用。由于后磨牙位置靠后...
医源资料库;在线期刊;中华医学研究杂志;2005年第5卷第12期果蝇中枢神经元离子通道的基因和电生理学研究进展
...已利用各种技术尤其是膜片钳技术对其进行研究。果蝇这一良好的实验材料使我们能将遗传学、分子生物学和电生理学等各种方法有机地结合起来,为无脊椎动物乃至脊椎动物神经元的信号转导、神经网络的信息加工及中枢神经...
医源资料库;在线期刊;中华中西医杂志;2006年第7卷第19期MolecularEvolutionofHumanInfluenzaA/H3N2VirusinAsiaandEuropefrom2001to2003
AppliedImmunologyandMicrobiologyDivision,WyethVaccinesResearch,PearlRiver,NewYork10965ABSTRACTHemagglutininsequencesof146humaninfluenzaA/H3N2strainsidentifiedinrespiratoryspecimensfromAsiaandEuropeduringthe2001-2003influenzaseasonswereanalyzedbyDNAsequencing.Ourresultssuggestthatfouraminoacidsubstit...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期Purifiedhematopoieticstemcellengraftmentofrarenichescorrectsseverelymphoiddeficiencieswithouthostconditioning
DepartmentofPathology,InstituteofCancerandStemCellBiologyandMedicine,StanfordUniversitySchoolofMedicine,Stanford,CA94305Intheabsenceofirradiationorothercytoreductiveconditioning,endogenoushematopoieticstemcells(HSCs)arethoughttofilltheuniquenicheswithinthebonemarrowthatallowmaintenanceoffullhematopo...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期Exvivobiomechanicalpropertiesofthefemaleurethrainaratmodelofbirthtrauma
【摘要】Stressurinaryincontinence(SUI)istheinvoluntaryreleaseofurineduringsuddenincreasesinabdominalpressures.SUIiscommoninwomenaftervaginaldeliveryorpelvictraumaandmayalterthebiomechanicalpropertiesoftheurethra.Thuswehypothesizethatinjuryduetovaginaldistension(VD)decreasesurethralbasaltoneandpa...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第4期β1(KCNMB1)SubunitsMediateLithocholateActivationofLarge-ConductanceCa2+-ActivatedK+ChannelsandDilationinSmall,Resistance-SizeArteries
【关键词】β1(KCNMB1)Amongthenongenomiceffectsofsteroids,controlofvasomotionhasreceivedincreasingattention.Lithocholate(LC)andotherphysiologicallyrelevantcholane-derivedsteroidscausevasodilation,yetthemoleculartargetsandmechanismsunderlyingthisactionremainlargelyunknown.WedemonstratethatLC(45&m...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期峰值14万亿次浪潮天梭助力生命科学探索
...所的科研效率。性能与需求的“超车”比赛生命科学作为一门在农业、医药、环保等领域有着广泛应用的实验科学,对高性能计算有着高度依赖。无论是蛋白质模拟还是海量基因数据的收集、筛选与排序,都离不开具有强大运算...
医学教育;科教新闻