DetectionofVi-NegativeSalmonellaentericaSerovarTyphiinthePeripheralBloodofPatientswithTyphoidFeverintheFaisalabadRegionofPakistan
....ThepathogenesisofthemembersofthegenusSalmonellaisattributed,inpart,totheacquisitionofhorizontallytransferredDNA,includingplasmids,prophage,andgeneislands(3,4,24,25,31).ArguablythemostimportantformofhorizontallytransferredDNAwithrespecttothepathogenesisofthesalmonellaeisthepossessionoflargegeneislan...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期CharacterizationofBorrelialusitaniaeIsolatesCollectedinTunisiaandMorocco
...alusitaniaeisaspecieswithinthecomplexBorreliaburgdorferisensulatoandisinfrequentlyisolatedinEurope.Incontrast,thisspeciesisbyfarthemostpredominantinNorthAfricaandinPortugal.Inthisstudy,weanalyzedthegeneticdiversity,atseveralloci,ofalargepopulationofisolatesfromfree-livingIxodesricinustickscollectedi...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期InvivoanalysisoftheroleofaberranthistonedeacetylaserecruitmentandRARblockadeinthepathogenesisofacutepromyelocyticleukemia
...Research,SirMortimerB.DavisJewishGeneralHospital,McGillUniversity,Montreal,QuebecH3T1E2,CanadaThepromyelocyticleukemia–retinoicacidreceptor(PML-RAR)proteinofacutepromyelocyticleukemia(APL)isoncogenicinvivo.IthasbeenhypothesizedthattheabilityofPML-RARtoinhibitRARfunctionthroughPML-dependentaberrant...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期聚乙二醇200基硝苯柳胺与钥孔戚血蓝蛋白的相互作用
...荧光猝灭是动态猝灭,则荧光强度可用Stern2Volmer方程F0/F=1+Kqτ0[Q]=1+KSV[Q]处理[7],以F0/F对[Q]作Stern2Volmer图,作Stern2Volmer曲线拟合,得出298K、310K、320K时双分子猝灭过程速率常数分别为3.73×1012、3.12×1012、2.88×1012L•mol-1•s-1,均大于...
药品天地;专业药学;实验技术;色谱技术;色谱论文Factorsaffectingstatisticalpowerinthedetectionofgeneticassociation
...abilityoflocalizingdiseasegenes.IntroductionTherecentcompletionofthedraftsequenceofthehumangenome(1,2)raisesinterestingpossibilitiesregardingtheapplicationofgenomics(seeGlossary)tomedicineinthetwenty-firstcentury(3).Bygenomics,wemeanthefunctionsandinteractionsofallgenesinthegenome.AsGuttmacherandCol...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期Real-TimeReverseTranscriptionPCRforDetectionandQuantitativeAnalysisofEquineInfluenzaVirus
VirologyUnit,IrishEquineCentre,Johnstown,Naas,CountyKildare,IrelandDepartmentofLifeSciences,UniversityofLimerick,Limerick,IrelandDepartmentofBiologicalSciences,DublinInstituteofTechnology,Dublin,IrelandABSTRACTEquineinfluenzaisacauseofepizooticrespiratorydiseaseoftheequine.Thedetectionofequineinflue...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第10期最新国内最具影响力的学术论文(生物类)
...一篇文章:“Ahumangutmicrobialgenecatalogueestablishedbymetagenomicsequencing”入选,文章公布了人体肠道菌基因组研究成果,这不仅将对人类自身健康与体内微生物的微妙关系做出科学的诠释,也更有助于预防、监控和干预由肠道菌群引发...
医药经济;生物技术;技术要闻ProtectiveimmuneresponsesagainstWestNilevirusareprimedbydistinctcomplementactivationpathways
...mentactivationpathwaystotheprotectionfromWNVdisease.GeneticdeficienciesinC1q,C4,factorB,orfactorDallresultedinincreasedmortalityinmice,suggestingthatallactivationpathwaysfunctiontogethertolimitWNVspread.Intheabsenceofalternativepathwaycomplementactivation,WNVdisseminatedintothecentralnervoussystemat...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第5期Thegeneticepidemiologyofneurodegenerativedisease
...tweenfamilial(rare)andseeminglynonfamilial(common)forms.Thelatterarealsofrequentlydescribedas“sporadic“or“idiopathic,“althoughthereisagrowingbodyofevidencesuggestingthatalargeproportionofthesecasesarealsosignificantlyinfluencedbygeneticfactors.Theseriskgenesarelikelytobenumerous,displayingin...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期AutoamplificationofNFATc1expressiondeterminesitsessentialroleinbonehomeostasis
...c2arefunctionallyredundantintheimmunesystem,butitwassuggestedthatNFATc1isrequiredexclusivelyfordifferentiationofosteoclastsintheskeletalsystem.HereweprovidegeneticevidencethatNFATc1isessentialforosteoclastdifferentiationinvivobyadoptivetransferofNFATc1–/–hematopoieticstemcellstoosteoclast-defici...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第9期