MonitoringInteractionsbetweenReceptorTyrosineKinasesandTheirDownstreamEffectorProteinsinLivingCellsUsingBioluminescenceResonanceEnergyTransf
...tyoftheirconstitutiveactivitytobeinhibitedbytheinhibitorimatinib(Gleevec).Epidermalgrowthfactorreceptor(EGFR)BRETstructure-functionstudiesidentifythetyrosineresidues1068,1114,and1148asthemainresiduesmediatingtheinteractionofEGFRwiththeadapterproteinGrb2.TheBRETtechnologyprovidesanassayplatformtostud...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期肺表面活性物质与哮喘的研究进展
...中PS具有抗炎作用,其可以显著降低气道炎症细胞的蛋白渗出[4]。PS中的SP-A和SP-D属于胶原凝集素,在肺部免疫中发挥重要作用。Hickling等[5]认为SP-A和SP-D不仅能识别和结合过敏原,阻止抗原致敏及变态反应的发生,且能抑制...
合作平台;在线期刊;中华实用医药杂志;2004年第4卷第17期;综述Associationsofsizeatbirthanddual-energyX-rayabsorptiometrymeasuresofleanandfatmassat9to10yofage
...om(JCKW);theDivisionofDevelopmentalMedicine,UniversityofGlasgow,YorkhillHospitals,Glasgow,UnitedKingdom(JRR);andtheDepartmentofClinicalSciencesatSouthBristol,UniversityofBristol,BristolRoyalInfirmary,Bristol,UnitedKingdom(JT)2SupportedbyagrantfromtheWellcomeTrust.TheUKMedicalResearchCouncil,theWellc...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第4期InternalizationofrenaltypeIIcNa-Picotransporterinresponsetoahigh-phosphatediet
...a,JapanABSTRACTDietaryphosphatelevelsregulatetherenalbrush-bordertypeIIaNa-Picotransporter.AnotherNa-Picotransporter,typeIIc,colocalizeswithtypeIIaNa-Picotransporterintheapicalmembraneofrenalproximaltubularcells.Thegoalofthepresentstudywastodeterminewhetherdietaryphosphatelevelsalsorapidlyregulateth...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第3期Hyperactivationofp21rasandPI3Kcooperatetoaltermurineandhumanneurofibromatosistype1–haploinsufficientosteoclastfunctions
...iththatinsyngeneicWTmice.IntercrossingNf1+/–miceandmicedeficientinclass1API3K(p85)restoredelevatedPI3KactivityandNf1+/–osteoclastfunctionstoWTlevels.Furthermore,invitro–differentiatedosteoclastsfromNF1patientsalsodisplayedelevatedRas/PI3Kactivityandincreasedlyticactivityanalogoustothoseinmurin...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期Inhibitionofphosphatidylinositol3-kinasestimulatesactivityofthesmall-conductanceKchannelintheCCD
...WeusedWesternblottingtoexaminetheexpressionofphosphatidylinositol3-kinase(PI3K)intherenalcortexandoutermedullaandemployedthepatch-clamptechniquetostudytheeffectofPI3KontheROMK-likesmall-conductanceK(SK)channelsinthecorticalcollectingduct(CCD).LowKintakeincreasedtheexpressionofthe110-kDa-subunit(p110...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第4期他莫昔芬联合顺铂对人卵巢癌细胞HO-8910增殖抑制作用的研究
...Ying,CHENYan-hua (DepartmentofObstetricsandGynecologyinRedCrossHospitalinShenyangCity,liaoning110033,China) 【Abstract】Purpose:Toinvestigatetheeffectoftamoxifen combinedwithcisplatinonthegrowthofhumanovariancancercell,andtoinsepecttheefficacythatTAMcombinedwithDDPsuppressedt...
医源资料库;在线期刊;中国民康医学;2008年第20卷第10期Theglycemicindexat20y
DavidSLudwigandRobertHEckel1FromtheDepartmentofMedicine,Children‘sHospital,Boston,andtheDepartmentofMedicine,UniversityofColoradoHealthScienceCenter,Denver.2AddressreprintrequeststoDSLudwig,DepartmentofMedicine,Children‘sHospital,300LongwoodAvenue,Boston,MA02115.E-mail:david.ludwig{at}tch.harvar...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第1期处在临床研究十字路口的靶向药PI3K
PI3K对于抗肿瘤药物的研发者来说是一个非常明显的靶标。被正式命名为磷脂酰肌醇-3-激酶(PI3K)的酶,所参与的人体内功能可以列出一串长长的清单,这些功能促成了细胞生存能力。通过向信号分子中加入磷酸,PI3K引发了一连...
药品天地;专业药学;药学研究SynthesisoftheNa-K-ATPase-subunitisregulatedatboththetranscriptionalandtranslationallevelsinIMCD3cells
...mediatedupregulationofthe-subunitofNa-K-ATPaseisdependentonboththeJNKandthePI3kinasepathways(ProcNatlAcadSciUSA98:13414,2001).Thepresentexperimentswereundertakentoexplorethemechanismswherebythesepathwaysregulatetheexpressionofthe-subunitininnermedullarycollectingductcells(IMCD3).InhibitionofJNKwithS...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第1期