Regulationofphosphatidylinositol3–kinasebypolyisoprenylphosphatesinneutrophil-mediatedtissueinjury
...CenterofExperimentalTherapeuticsandReperfusionInjury,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA021152DepartmentofChemistry,UniversityofSouthernCalifornia,CA90089Neutrophilsplayacentralroleinhostdefense,inflammation,andtissueinjury.Recentfindingsindicateanovelroleforpolyisoprenylpho...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期EmergencyAdministrationofAbciximabforTreatmentofPatientsWithAcuteIschemicStroke
...tPA.3RecurrentocclusionmightbesecondarytoprocoagulanteffectsofrtPA,andtherapiestocounteracttheseactionsareneeded.4Hence,thereisaneedforreperfusionagentsthatcouldbesafelyadministeredinalongertimewindow.Activationofplateletsisakeycomponentofacutethromboembolismandexperimentalstudiesalreadydemonstratet...
医源资料库;在线期刊;中风学杂志;2005年第36卷第4期彩色多普勒超声检测早期移植肾急性排斥临床价值探讨
...弓状动脉、小叶间动脉血流阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(Vp)等参数进行分析。结果以肾动脉Vp110cm/s,RI0.74,PI1.81、小叶间动脉RI=1作为移植肾早期急性排斥诊断标准,则敏感性92%、特异性88%。结论应用彩...
合作平台;在线期刊;中华现代临床医学杂志;2004年第2卷第7B期ProtectionfromangiotensinII–mediatedvasculotoxicandhypertensiveresponseinmicelackingPI3K
...el,Switzerland4DipartimentodiMedicinaSperimentaleePatologia,UniversitàLaSapienzadiRoma,00161Roma,ItalyHypertensionaffectsnearly20%ofthepopulationinWesterncountriesandstronglyincreasestheriskforcardiovasculardiseases.Inthepathogenesisofhypertension,thevasoactivepeptideoftherenin-angiotensinsystem,an...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期PI3Kintegratestheactionofinsulinandleptinonhypothalamicneurons
...shington,USA.AbstractCentralcontrolofenergybalancedependsontheabilityofproopiomelanocortin(POMC)oragouti-relatedprotein(Agrp)hypothalamicneuronstosenseandrespondtochangesinperipheralenergystores.Leptinandinsulinhavebeenimplicatedascirculatingindicatorsofadiposity,butitisnotclearhowchangesintheirleve...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期PolymorphismoftheHumanImmunodeficiencyVirusType2(HIV-2)ProteaseGeneandSelectionofDrugResistanceMutationsinHIV-2-InfectedPatientsTreatedwi
HpitalBichat-ClaudeBernardINSERMU552,ParisINSERMU330,Bordeaux,FranceInstitutPasteur,Dakar,SenegalABSTRACTWedescribedthebaselinepolymorphismofthehumanimmunodeficiencyvirustype2(HIV-2)proteasegenefrom94treatment-naivepatientsandthelongitudinalfollow-upof17proteaseinhibitor-treatedpatients.Comparedtoth...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期Intermittentpressureoverloadtriggershypertrophy-independentcardiacdysfunctionandvascularrarefaction
...dtherolesofdurationandnatureofthestressonthedevelopmentofcardiacfailure.Despiteamildhypertrophicresponse,preservedsystolicfunction,andafavorablefetalgeneexpressionprofile,heartsexposedtointermittentpressureoverloaddisplayedpathologicalfeatures.Importantly,intermittentpressureoverloadcauseddiastolicd...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期RegulationofanaphylacticresponsesbyphosphatidylinositolphosphatekinasetypeI
...harmacology,StateUniversityofNewYork,StonyBrook,NY11794Themembranephospholipidphosphatidylinositol4,5-bisphosphate[PI(4,5)P2]isacriticalsignaltransducerineukaryoticcells.However,thephysiologicalrolesofthetypeIphosphatidylinositolphosphatekinases(PIPKIs)thatsynthesizePI(4,5)P2arelargelyunknown.Here,w...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期UltrasoundStimulatesCyclooxygenase-2ExpressionandIncreasesBoneFormationthroughIntegrin,FocalAdhesionKinase,Phosphatidylinositol3-Kinase,andAkt
...tegrin,attenuatedtheUS-inducedCOX-2expression.Phosphatidylinositol3-kinase(PI3K)inhibitors2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-onehydrochloride(LY294002)andwortmanninalsoinhibitedthepotentiatingactionofUS.USstimulationincreasedthephosphorylationoffocaladhesionkinase(FAK),extracellularsignal...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期Anti-CD63antibodiessuppressIgE-dependentallergicreactionsinvitroandinvivo
...)inducessecretionofpreformedallergymediators(degranulation)andsynthesisoflipidmediatorsandcytokines.Degranulationproducesmanysymptomsofimmediate-typeallergicreactionsandismodulatedbyadhesiontosurfacescoatedwithspecificextracellularmatrix(ECM)proteins.Thesignalsinvolvedinthismodulationaremostlyunknow...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期