FunctionalinfluenceofN-glycosylationinOCT2-mediatedtetraethylammoniumtransport
【摘要】OCT2,anorganiccationtransportercriticalforremovalofmanydrugsandtoxinsfromthebody,containsconsensussitesforN-glycosylationataminoacidposition71,96,and112.However,theextenttowhichthesesitesareglycosylatedbythecell,andtheinfluenceglycosylationhasonOCT2function,remainsunknown.Toaddressthesei...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期丙型肝炎病毒包膜蛋白E2人源单链可变区抗体的筛选与鉴定
...菌体抗体文库为轻链可变区和重链可变区经甘氨酸接头(Gly4Ser)3连接的抗体文库。辅助噬菌体M13K07购于Pharmacia公司,Wizard质粒DNA提取纯化试剂盒购于Promega公司。其他试剂均为国产分析纯。 1.2特异性HCVE2噬菌体人源单链...
合作平台;医学论文;临床医学与专科论文;检验医学Anautosomaldominantmajorgeneconferspredispositiontopulmonarytuberculosisinadults
1LaboratoryofImmunology,MilitaryHospitalMohamedV,HayRiadRabat,Morocco2McGillCentrefortheStudyofHostResistance,DepartmentsofHumanGeneticsandMedicine,McGillUniversity,MontrealGeneralHospital,Montreal,PQ,H3G1A4Canada3LaboratoryofHumanGeneticsofInfectiousDiseases,InstitutNationaldelaSanteetdelaRecherche...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期茚地普隆的合成工艺改进
...化学;制备;化学合成AnimprovedsynthesismethodofindilplonSHAOQiu-rong,WUJin-chang.ShundeEntry-ExitInspectionandQuarantineBureauAgriculturalandChemicalProductsLaboratory,Shunde528303,China【Abstract】ObjectiveTosynthesisindiplon.MethodsThesynthesisstartedfromcommerciallyavailableof2-acetylthio...
医源资料库;在线期刊;中华实用医药杂志;2006年第6卷第20期DelvingdeeperintoMALTlymphomabiology
LaboratoryofExperimentalOncologyandLymphomaUnit,OncologyInstituteofSouthernSwitzerland,Bellinzona,Switzerland.AbstractMucosa-associatedlymphoidtissue(MALT)lymphomascanariseinavarietyofextranodalsites.Interestingly,atleast3different,apparentlysite-specific,chromosomaltranslocations,allaffectingtheNF-...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期SingleMutationsatAsn295andLeu305intheCytoplasmicHalfofTransmembrane-HelixDomain7oftheAT1ReceptorInducePromiscuousAgonistSpecificityfor
DepartmentofPharmacology,UniformedServicesUniversityoftheHealthSciences,Bethesda,Maryland(Y.-H.F.,R.Q.)DepartmentofMedicine,CWRUSchoolofMedicine,Cleveland,Ohio(L.Z.,R.Z.)AbstractThemoststrikingfeatureofaGprotein-coupledreceptor(GPCR)isitshighlyexclusiveagonistspecificity.ThisfeatureguaranteesthataGP...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期生物丁醇合成关键酶的新型开关机制的解析
...限性及其代谢的复杂性,当前丁醇批次发酵浓度仍低于20g/L。对产溶剂梭菌代谢复杂性的深入了解,或许能开启高产丁醇细胞工厂的大门。而CaTHL结构和调节功能的解析似乎就是开启这扇大门的开端。1)CaTHL氧化和还原态的结构...
医药经济;生物技术;技术要闻CystamineandcysteamineincreasebrainlevelsofBDNFinHuntingtondiseaseviaHSJ1bandtransglutaminase
1InstitutCurie,CNRSUMR146,Orsay,France.2DepartamentdeBiologiaCellulariAnatomiaPatològica,FacultatdeMedicina,Institutd’InvestigacionsBiomèdiques,UniversitatdeBarcelona,Barcelona,Spain.3INSERM,AvenirGroup,LaboratoryofGenomicBiology,CentrePaulBroca,Paris,France.4URACEA/CNRS2210,ServiceHospitalierFr...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期Androgen-dependentpathologydemonstratesmyopathiccontributiontotheKennedydiseasephenotypeinamouseknock-inmodel
1DepartmentofPathology,2DepartmentofHumanGenetics,and3DepartmentofNeurology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,USA.4DepartmentofPsychologyandNeuroscienceProgram,MichiganStateUniversity,EastLansing,Michigan,USA.AbstractKennedydisease,adegenerativedisordercharacterizedbyandrogen-depen...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期中图法分类号查询(全部简表)
...---------------------------------------------------------U 交通运输U1综合运输U2铁路运输U4公路运输U6水路运输U[8]航空运输--------------------------------------------------------------------------------V航空、航天V1航空、航天技术的研究与探索V2航空V4航天...
药品天地;专业药学;实验技术;基本实验技术;实验数据