KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissues
...atory,GenomicsDivision,Berkeley,California,USA.AbstractScavengerreceptorSR-BIhasbeenimplicatedinHDL-dependentatheroprotectivemechanisms.WereportthegenerationofanSR-BIconditionalknockoutmousemodelinwhichSR-BIgenetargetingbyloxPsiteinsertionproducedahypomorphicallele(hypomSR-BI).AttenuatedSR-BIexpress...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期RelativeContributionsofABCA1andSR-BItoCholesterolEffluxtoSerumFromFibroblastsandMacrophages
...tohumanserum.MethodsandResults-HumanfibroblastswerestablytransfectedwithSR-BIwhileABCA1wasupregulated.Quantitationofcholesteroleffluxtohumanserumdemonstratedthattherewaseffluxfromcellswithouteitherprotein.ExpressionofABCA1producedasmallincreaseinefflux,whereasSR-BIexpressionhadadramaticimpact.Toquan...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第3期Cholesterolbinding,efflux,andaPDZ-interactingdomainofscavengerreceptor–BImediateHDL-initiatedsignaling
...ia,Pennsylvania,USA.5DepartmentofMedicine,DivisionofMolecularMedicine,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYork,USA.AbstractThebindingofHDLtoscavengerreceptor–BI(SR-BI)mediatescholesterolmovement.HDLalsoinducesmultiplecellularsignals,whichinendotheliumoccurthroughSR-BIandcon...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期DifferentialAdditiveEffectsofEndothelialLipaseandScavengerReceptor-ClassBTypeIonHigh-DensityLipoproteinMetabolisminKnockoutMouseModels
...crinologyandMetabolism(K.M.,L.C.),DepartmentsofMedicineandMolecularCellularBiology,BaylorCollegeofMedicine,andSt.Luke’sEpiscopalHospital,Houston,Tex;LawrenceBerkeleyNationalLaboratory(T.F.),Berkeley,Calif;andLipoScience(J.D.O.),Raleigh,NC.CorrespondencetoLawrenceChan,DivisionofEndocrinologyMetabol...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期CholesterylEsterTransferProtein(CETP)ExpressionProtectsAgainstDietInducedAtherosclerosisinSR-BIDeficientMice
...ssionofthehumanCETPtransgeneprotectsagainstdiet-inducedatherosclerosisinSR-BIdeficientmice.MethodsandResults-SR-BIdeficient(-/-)micewerecrossedwithCETPtransgenic(CETPtg)micetoproduceacolonyofSR-BI-/-xCETPtgmiceinaC57Bl/6background.Ageandsexmatchedgroupsofgeneticallymodifiedandwild-typeC57Bl/6micewer...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第4期MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
...】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescuethelethal...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期HCV蛋白酶抑制剂BI201335有强效抗病毒活性
...林格殷格翰公司研发的丙肝病毒(HCV)NS3/4A蛋白酶抑制剂BI201335,在初治和经治的慢性基因1型丙肝病毒(HCV)感染患者中的优异疗效。基因1型的HCV是在所有HCV感染治疗中最有挑战性的基因分型。 丙型肝炎是肝脏感染性疾病...
行业资讯;临床快报;肝胆病ScavengerReceptorClassBTypeIMediatestheSelectiveUptakeofHigh-DensityLipoprotein–AssociatedCholesterylEsterbytheLiverinMice
...H.G.,M.M.,F.R.),Hamburg,Germany;andtheCollegeofPhysiciansandSurgeonsofColumbiaUniversity(R.R.),NewYork,NY.CorrespondencetoDrFranzRinninger,UniversityHospitalHamburg-Eppendorf,DepartmentofMedicine,Martinistrasse52,20246Hamburg,Germany.E-mailRinninger@uke.uni-hamburg.deAbstractObjective—High-density...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期Bi-PAP呼吸机通气治疗慢性阻塞性肺疾病合并呼吸衰竭
【摘要】目的研究无创Bi-PAP呼吸机治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭。方法52例患者随机分为治疗组27例,持续Bi-PAP呼吸机治疗;对照组25例,持续低流量吸氧。两组同时抗感染等常规治疗。观察血气和临床症状变化。结...
合作平台;在线期刊;中华现代临床医学杂志;2005年第3卷第9期