HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo

...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...

KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissues

...atory,GenomicsDivision,Berkeley,California,USA.AbstractScavengerreceptorSR-BIhasbeenimplicatedinHDL-dependentatheroprotectivemechanisms.WereportthegenerationofanSR-BIconditionalknockoutmousemodelinwhichSR-BIgenetargetingbyloxPsiteinsertionproducedahypomorphicallele(hypomSR-BI).AttenuatedSR-BIexpress...

Bi-PAP呼吸机通气治疗慢性阻塞性肺疾病合并呼吸衰竭

【摘要】目的研究无创Bi-PAP呼吸机治疗慢性阻塞性肺疾病（COPD）合并呼吸衰竭。方法52例患者随机分为治疗组27例，持续Bi-PAP呼吸机治疗;对照组25例，持续低流量吸氧。两组同时抗感染等常规治疗。观察血气和临床症状变化。结...

Cholesterolbinding,efflux,andaPDZ-interactingdomainofscavengerreceptor–BImediateHDL-initiatedsignaling

...ia,Pennsylvania,USA.5DepartmentofMedicine,DivisionofMolecularMedicine,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYork,USA.AbstractThebindingofHDLtoscavengerreceptor–BI(SR-BI)mediatescholesterolmovement.HDLalsoinducesmultiplecellularsignals,whichinendotheliumoccurthroughSR-BIandcon...

RelativeContributionsofABCA1andSR-BItoCholesterolEffluxtoSerumFromFibroblastsandMacrophages

...tohumanserum.MethodsandResults-HumanfibroblastswerestablytransfectedwithSR-BIwhileABCA1wasupregulated.Quantitationofcholesteroleffluxtohumanserumdemonstratedthattherewaseffluxfromcellswithouteitherprotein.ExpressionofABCA1producedasmallincreaseinefflux,whereasSR-BIexpressionhadadramaticimpact.Toquan...

赛莱乐治疗42例缺血性脑卒中疗效观察

...莱乐150mg静脉点滴。疗程15天。结束后评定NFD程度、FMA及BI得分的变化，观察不良反应。结果2例赛莱乐组病人因不良反应退出观察，余82例完成观察。赛莱乐组、对照组的总有效率分别为83%、62%(P＜0.05)。治疗后NFD、FMA、BI评分分别...

清华大学物理化学试题（硕士）1998年

...)的标准摩尔生成焓△fＨm（HCl,aq）=_______。　　3、下图为Bi-Zn二组分体系的固液平衡相图，　　（１）A区的平衡相态为______,　　　　　B区的平衡相态为________。　　（２）527K时，纯Bi(s)和含93%Bi（质量百分数）的溶液成相平衡。...

High-DensityLipoproteinPromotesEndothelialCellMigrationandReendothelializationviaScavengerReceptor-BTypeI

...rationinvitroinanitricoxide-independentmannerviascavengerreceptorBtypeI(SR-BI)-mediatedactivationofRacGTPase.ThisprocessdoesnotrequireHDLcargomolecules,anditisdependentontheactivationofSrckinases,phosphatidylinositol3-kinase,andp44/42mitogen-activatedproteinkinases.Rapidinitialstimulationoflamellipo...

Bi-PAP无创鼻罩呼吸机治疗慢性阻塞性肺疾病的护理

【摘要】目的探讨Bi-PAP无创鼻罩呼吸机治疗慢性阻塞性肺疾疾（COPD）呼吸衰竭的护理。方法35例COPD呼吸衰竭患者在常规治疗的同时，应用Bi-PAP呼吸机S/T模式辅助通气治疗。结果经无创正压通气，31例好转，4例病情加重予以气管...

HepaticLipaseDeficiencyDelaysAtherosclerosis,MyocardialInfarction,andCardiacDysfunctionandExtendsLifespaninSR-BI/ApolipoproteinEDoubleKnockou

【摘要】Objective-SR-BI/apolipoprotein(apo)Edoubleknockout(dKO)miceexhibitmanyfeaturesofhumancoronaryheartdisease(CHD),includingocclusivecoronaryatherosclerosis,cardiachypertrophy,myocardialinfarctions,andprematuredeath.Herewedeterminedtheeffectsonthispathologyofhepaticlipase(HL)deficiency,which...