Gadd45andGadd45arecriticalforregulatingautoimmunity
...unity.Here,weshowthattwomembersofthegrowtharrestandDNAdamage-inducible(Gadd45)family,and,arecriticalinthedevelopmentofpathogeniceffectorTcells.CD4+TcellslackingGadd45canrapidlyexpandandinvadethecentralnervoussysteminresponsetomyelinimmunization,provokinganexacerbatedandprolongedautoimmuneencephalomy...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第10期MyosinIICo-ChaperoneGeneralCellUNC-OverexpressionIsAssociatedwithOvarianCancerRapidProliferationandMotility
...BothtumorcellproliferationandmetastasisaredependentonmyosinII.BecauseUNC-45isrequiredtochaperonetheassemblyofafunctionalmyosinIImotor,weexaminedtheexpressionofthegeneralcell(GC)UNC-45isoforminovariantumors.SerouscarcinomaexpressedelevatedlevelsofGCUNC-45comparedwithnormalovariansurfaceepitheliumandb...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期ReplacementofConnexin40byConnexin45intheMouseImpactonCardiacElectricalConduction
FromtheLaboratoiredeGénétiqueetPhysiologieduDéveloppement(UMRCNRS6545)(S.A.,T.J.-G.,D.G.),InstitutdeBiologieduDéveloppementdeMarseille,UniversitédelaMéditerranée,Marseille,France;DepartmentofMedicalPhysiology(H.v.R.,H.J.),UniversityMedicalCenter,Utrecht,TheNetherlands;NeurologiaExperimental(D...
医源资料库;在线期刊;循环研究杂志;2004年第94卷第1期EndothelialOutgrowthCellsAreNotDerivedFromCD133+CellsorCD45+HematopoieticPrecursors
...beenusedtoidentifyputativecirculatingendothelialprecursors.WealsoincludedCD45intheanalysistoassesstherelationbetweenCD34+hematopoieticprogenitors(HPC),CD34+endothelialprecursors,andbothinvitrogeneratedEPCtypes.Addressingthisissuemightleadtoabetterunderstandingofthelineageandphenotypeoftheprecursor(s...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期Effectsofexpressionofp53andGadd45onosmotictoleranceofrenalinnermedullarycells
...y(IM)collectingductcells(mIMCD3)tohighNaClinvolvesincreasedexpressionofGadd45andp53,bothofwhichhaveimportanteffectsongrowthandsurvivalofthecells.However,mIMCD3cells,beingimmortalizedbySV40,proliferaterapidly,whichisknowntosensitizecellstohighNaCl,whereasIMcellsinsituproliferateveryslowlyandsurvivemu...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期平肝舒络丸
...色谱相应的位置上,显相同颜色的荧光斑点。处方柴胡 45g 青皮(醋炙) 60g 陈皮 45g佛手 45g 乌药 45g 香附(醋炙) 45g木香 45g 檀香 45g 丁香 60g沉香 150g 广藿香 45g 砂仁 45g豆蔻仁 45g 厚朴(姜炙)...
药品天地;专业药学;中国药典;2000版一部二、CD45在信号转导中的调节作用
二、CD45在信号转导中的调节作用 (一)CD45在活化信号转导中的调节作用 在确定CD45为一种PTPase之前就已证实了CD45参于细胞的活化和生长调节。抗CD45抗体可以(1)抑制PHA或CD3交联所介导的T细胞增殖;(2)抑制NK或细胞...
医源资料库;医源图书馆;教材类;细胞和分子免疫学StructuralbasisforthefunctionandregulationofthereceptorproteintyrosinephosphataseCD45
...n,MA021153InstituteofMedicalScience,UniversityofTokyo,Tokyo108-8639,JapanCD45istheprototypicmemberoftransmembranereceptor-likeproteintyrosinephosphatases(RPTPs)andhasessentialrolesinimmunefunctions.ThecytoplasmicregionofCD45,likemanyotherRPTPs,containstwohomologousproteintyrosinephosphatasedomains,a...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期1HowardHughesMedicalInstitute,UniversityofAlabamaatBirmingham,Birmingham,AL35294
...rrentlyunclear.InthisstudyweinvestigatetheroleofthecellsurfacephosphataseCD45inNKcelldevelopmentandintracellularsignalingfromactivatingreceptors.StimulationviathemajorhistocompatibilitycomplexI–bindingreceptor,Ly49DonCD45–/–primaryNKcellsresultedintheactivationofphosphoinositide-3-kinaseandnor...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第9期CD45MOLECULEANDGENERATIONOFEPIDERMALγδTCELLSFROMMIC
CD45MOLECULEANDGENERATIONOFEPIDERMALγδTCELLSFROMMIC免疫学杂志1999年第2期第15卷基础免疫学作者:CaiQinchao(蔡钦朝)1,WangBinghe(王秉鹤)2关键词:词CD45蛋白酪氨酸磷酸酶;树突状表皮T细胞;γδT细胞;T细胞发育(1DepartmentofBiochemistry,Anhu...
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