Connexin43DownregulationandDephosphorylationinNonischemicHeartFailureIsAssociatedWithEnhancedColocalizedProteinPhosphataseType2A
...e-entry)thatcouldarisefromchangesingapjunctionalproteins,especiallyconnexin43(Cx43).WestudiedCx43expressionandphosphorylationstateintheleftventricle(LV)fromanarrhythmogenicrabbitmodelofnonischemicHFandfrompatientswithHFattributabletoidiopathicdilatedcardiomyopathy.Wealsoinvestigatedtheroleofproteinp...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第1期ASertoliCell-SpecificKnockoutofConnexinPreventsInitiationofSpermatogenesis
【摘要】Thepredominanttesticulargapjunctionalproteinconnexin43(cx43)islocatedbetweenneighboringSertolicells(SCs)andbetweenSCsandgermcells.Itisassumedtobeinvolvedintesticulardevelopment,celldifferentiation,initiation,andmaintenanceofspermatogenesiswithalterationsofitsexpressionbeingcorrelatedwith...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期ImpairmentofDiazoxide-InducedFormationofReactiveOxygenSpeciesandLossofCardioprotectioninConnexin43DeficientMice
...schemicpreconditioningislostincardiomyocytesandheartsofheterozygousconnexin43deficient(Cx43+/eC)mice.Becauseconnexin43(Cx43)islocalizedincardiomyocytemitochondriaandmitochondrialCx43contentisincreasedwithischemicpreconditioning,wenowtriedtoidentifyafunctionaldefectatthelevelofthemitochondriainCx43+/...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第9期SmoothMuscle-TargetedKnockoutofConnexin43EnhancesNeointimalFormationinResponsetoVascularInjury
...ve-Vasculardiseasealtersandreducesconnexinexpressionandareductioninconnexin43(Cx43)expressiondiminishestheextentofatherosclerosisobservedinahigh-cholesteroldietmurinemodel.Wehypothesizedthatconnexinsmightplayaroleinthesmoothmusclecellresponsetovascularinjury.MethodsandResults-Wethereforestudiedaline...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期SynergisticeffectsofPDGF-BBandcAMP-elevatingagentsonexpressionofconnexin43inmesangialcells
...ofcellstoPDGFcausesrapidandtransientdisruptionofGJICwithoutalteringconnexin43(Cx43)proteinlevel.Inthisstudy,weinvestigatedlong-termeffectsofPDGF-BBonCx43expressioninmesangialcells(MCs).ExposureofMCstoPDGF-BBaffectedneithertheCx43proteinlevelnorGJIC.However,inthepresenceofcAMP-elevatingagents,PDGF-BB...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期FunctionalCharacterizationofConnexin43MutationsFoundinPatientsWithOculodentodigitalDysplasia
...bstractSpecificmutationsinGJA1,thegeneencodingthegapjunctionproteinconnexin43(Cx43),causeanautosomaldominantdisordercalledoculodentodigitaldysplasia(ODDD).Here,wecharacterizetheeffectsof8ofthesemutationsonCx43function.Immunochemicalstudieshaveshownthatmostofthemutantproteinsformedgapjunctionplaquesa...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第5期Variablegp43SecretionbyParacoccidioidesbrasiliensisClonesObtainedbyTwoDifferentCultureMethods
...omethods(micromanipulationandplatingassay)andtodetermineifthesecretionofthe43-kDaglycoprotein(gp43)isdependentontheclonalculture.Theresultsshowthatthesecretionofgp43isnotdependentonclonalcultures.Clonesthatoriginallyweresecretorsofthismolecule,aftersubculturing,lostthischaracteristic;ontheotherhand,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期EnhancedFunctionalGapJunctionNeoformationbyProteinKinaseAeCDependentandEpac-DependentSignalsDownstreamofcAMPinCardiacMyocytes
...dbytheproteinkinaseA(PKA)eCdependentsignal,andthattheaccumulationofconnexin43(Cx43),themostabundantCxinmyocytes,isenhancedbyanexchangeproteindirectlyactivatedbycAMP(Epac)(Rap1activator)eCdependentsignal.ThegatingfunctionofGJswasanalyzedbymicroinjecteddyetransfermethod.TheaccumulationofCx43wasanalyze...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第9期MatrixProteineCSpecificRegulationofCx43ExpressioninCardiacMyocytesSubjectedtoMechanicalLoad
...axial,pulsatilestretch.Changesinexpressionofthecardiacgapjunctionprotein,Cx43,weremeasuredbyconfocalmicroscopyandimmunoblotting.CellsgrownonfibronectinordenaturedcollagenexhibitedsignificantlygreaterCx43expressionthancellsgrownonnativecollagen.Stretchinduceda2-foldincreaseinCx43expressionincellsgrow...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第3期TDP-inFamilialandSporadicFrontotemporalLobarDegenerationwithUbiquitinInclusions
【摘要】TARDNA-bindingprotein43(TDP-43)isamajorpathologicalproteinofsporadicandfamilialfrontotemporallobardegenerationwithubiquitin-positive,tau-negativeinclusions(FTLD-U)withorwithoutmotorneurondisease(MND).Thus,TDP-43definesanovelclassofneurodegenerativediseasescalledTDP-43proteinopathies.Wepe...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期