Cholesterol-Dependentand-IndependentCD40InternalizationandSignalingActivationinCardiovascularEndothelialCells
【摘要】Objective—ItremainselusivehowCD40endocytosisorclusteringonthecellsurfaceisinducedbydifferentformsofCD40agonist.ThisstudyaimstoinvestigatewhetherlipidraftsdifferentiallyregulateCD40trafficandsignalinginproinflammatoryactivationofcardiovascularendothelialcells(ECs).MethodsandResults&...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第9期AnthocyaninPreventsCD40-ActivatedProinflammatorySignalinginEndothelialCellsbyRegulatingCholesterolDistribution
...receptor-associatedfactors(TRAFs)translocationtolipidraftsisakeyelementinCD40-inducedsignaling.ThepurposeofthisstudywastoinvestigatetheinfluenceofanthocyaninonCD40-mediatedproinflammatoryeventsinhumanendothelialcellsandtheunderlyingpossiblemolecularmechanism.MethodsandResults-Treatmentofendothelialc...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第3期BiologicallyActiveCD40LigandIsElevatedinSickleCellAnemia
【摘要】Objective-Afteractivation,plateletsexposeCD40ligand(CD40L)ontheirsurface,thensubsequentlyreleasetheinflammatorymediatorasasolublefragment(sCD40L).Becausesicklecellanemia(SCA)isnotedforbothplateletactivationandchronicinflammation,weaskedwhetherplatelet-releasedCD40Lpotentiallyplaysarolein...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第7期SolubleCD40LLevelsAreRegulatedbythe-3459AGPolymorphismandPredictMyocardialInfarctionandtheEfficacyofAntithromboticTreatmentinNon-STEleva
【摘要】Objectives-CurrentevidencesuggeststheCD40-CD40Lpathwayasakeyprocessinthedevelopment,progression,andoutcomeofacutecoronarysyndrome(ACS).Theaimwastoinvestigatetheprognosticimportanceofsoluble(s)CD40Llevels,singlenucleotidepolymorphisms(SNP)intheCD40LGgene,andtherelationbetweensCD40LandSNPs...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第7期AssociationsBetweenSolubleCD40Ligand,AtherosclerosisRiskFactors,andSubclinicalAtherosclerosis
...urposeofthisstudywastoevaluatetheassociationsbetweenplasmalevelsofsolubleCD40ligand(sCD40L),atherosclerosisriskfactors,andevidenceofsubclinicalatherosclerosis.MethodsandResults—PlasmalevelsofsCD40Lweremeasuredin2811subjectsfromtheDallasHeartStudy,amultiethnicpopulation-basedcross-sectionalstudy.El...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第10期ReplacementofConnexin40byConnexin45intheMouseImpactonCardiacElectricalConduction
...nofcardiacimpulse,areintercellularstructurescomposedofconnexins(Cx).Cx43,Cx40,andCx45aresynthesizedinthecardiomyocytes,andeachofthemhasauniquecardiacexpressionpattern.Cx40knock-inCx45miceweregeneratedtoexploretheabilityofCx45toreplaceCx40,andtoassessthefunctionalequivalenceofthesetwoCxsthatarebothex...
医源资料库;在线期刊;循环研究杂志;2004年第94卷第1期InterruptionoftheTnfrsf4/Tnfsf4(OX40/OX40L)PathwayAttenuatesAtherogenesisinLow-DensityLipoproteinReceptor-DeficientMice
...mmatorydiseaseandTcellactivationisanimportantfactorinthisprocess.Tnfrsf4(OX40)andTnfsf4(OX40ligand)aremembersofthetumornecrosisfactor(TNF)andTNFreceptorfamilyandOX40/OX40Lmediatedsignalingisimportantinco-activationofTcellsandfacilitatesB-Tcellinteraction.InthisstudyweassessedtheroleoftheOX40/OX40Lpa...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第1期TRAF-1,-2,-3,-5,and-6AreInducedinAtheroscleroticPlaquesandDifferentiallyMediateProinflammatoryFunctionsofCD40LinEndothelialCells
【摘要】Objective-SeverallinesofevidenceimplicateCD40ligand(CD40L,CD154)asamediatorandmarkerofatherosclerosis.Thisstudyinvestigatedtheinvolvementoftumornecrosisfactorreceptor-associatedfactors(TRAFs)inCD40signalinginendothelialcells(ECs)andtheirexpressioninatheromataandcellsinvolvedinatherogenes...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期CD40L-PositivePlateletsInduceCD40LExpressionDeNovoinEndothelialCells:AddingaLooptoMicrovascularInflammation
...ticlebyWagneretal,inwhichtheauthorselegantlyshowedthatmembraneboundCD154(CD40ligand)expressedbyT-cellscaneffectivelytriggerCD40Lexpressionbyendothelialcells.Moreimportantly,theauthorsdemonstratedafunctionalactivityofendothelium-associatedCD40L,thusrevealinganovelcostimulatoryactivityinmonocyte–end...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第9期CD40分子在肾癌组织中的表达研究
【摘要】目的探讨肾癌组织中CD40分子的表达与癌发生浸润转移的关系。方法用免疫组织化学二步法(Envision法)对甲醛固定石蜡包埋的肾细胞癌组织(32例)和癌旁组织(10例)中CD40的表达情况进行研究,并分析CD40分子表达水平与肾癌临...
医源资料库;在线期刊;现代泌尿外科杂志;2008年第12卷第4期